{"doi":"10.1182/blood.2020009428","title":"A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis","abstract":"Events mediated by the P-selectin/PSGL-1 pathway play a critical role in the initiation and propagation of venous thrombosis by facilitating the accumulation of leukocytes and platelets within the growing thrombus. Activated platelets and endothelium express P-selectin, which binds P-selectin glycoprotein ligand-1 (PSGL-1) that is expressed on the surface of all leukocytes. We developed a pegylated glycomimetic of the N terminus of PSGL-1, PEG40-GSnP-6 (P-G6), which proved to be a highly potent P-selectin inhibitor with a favorable pharmacokinetic profile for clinical translation. P-G6 inhibits human and mouse platelet-monocyte and platelet-neutrophil aggregation in vitro and blocks microcirculatory platelet-leukocyte interactions in vivo. Administration of P-G6 reduces thrombus formation in a nonocclusive model of deep vein thrombosis with a commensurate reduction in leukocyte accumulation, but without disruption of hemostasis. P-G6 potently inhibits the P-selectin/PSGL-1 pathway and represents a promising drug candidate for the prevention of venous thrombosis without increased bleeding risk.","journal":"Blood","year":2021,"id":156929,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281708,"name":"Dayoung Park","orcid":"0000-0003-4983-4340","position":1,"is_corresponding":false},{"id":281711,"name":"Simon Park","orcid":"0000-0001-8948-7641","position":2,"is_corresponding":false},{"id":347944,"name":"Carolyn A. Haller","orcid":"0000-0003-1963-3695","position":3,"is_corresponding":false},{"id":347943,"name":"Jiaxuan Chen","orcid":"0000-0001-5801-9052","position":4,"is_corresponding":false},{"id":663958,"name":"Erbin Dai","orcid":null,"position":5,"is_corresponding":false},{"id":662898,"name":"Liying Liu","orcid":"0000-0001-5678-7808","position":6,"is_corresponding":false},{"id":455773,"name":"Appi Reddy Mandhapati","orcid":null,"position":7,"is_corresponding":false},{"id":496482,"name":"Pradheep Eradi","orcid":null,"position":8,"is_corresponding":false},{"id":662899,"name":"Bibek Dhakal","orcid":"0000-0003-3958-5029","position":9,"is_corresponding":false},{"id":540815,"name":"Walter J. Wever","orcid":"0000-0002-5754-0652","position":10,"is_corresponding":false},{"id":379746,"name":"Melinda S. Hanes","orcid":null,"position":11,"is_corresponding":false},{"id":347955,"name":"Lijun Sun","orcid":"0000-0002-1579-2253","position":12,"is_corresponding":false},{"id":231529,"name":"Richard D. Cummings","orcid":"0000-0002-8918-5034","position":13,"is_corresponding":false},{"id":347956,"name":"Elliot L. Chaikof","orcid":"0000-0001-6184-4571","position":14,"is_corresponding":false},{"id":347947,"name":"Daniel J. Wong","orcid":"0000-0002-7093-3397","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T23:44:17.471040Z","pmid":"33945603","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}