{"doi":"10.1182/blood.2020005492","title":"Sensitizing Burkitt lymphoma to EBV-CTLs","abstract":null,"journal":"Blood","year":2020,"id":604632,"datarank":0.515782337054381,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.20386610580240563,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.20386610580240563,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":7,"citers_with_citation_signal":6,"citers_with_endowment":6,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254048,"name":"Helen E. Heslop","orcid":"0000-0001-7049-7698","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sensitizing Burkitt lymphoma to EBV-CTLs","abstract":"In this issue of Blood, Dalton et al(1) show that epigenetic therapy with decitabine can upregulate immunogenic Epstein-Barr virus (EBV) antigens on Burkitt lymphoma (BL) that normally only express the less immunogenic antigen EBV nuclear antigen-1 (EBNA-1), rendering them sensitive to EBV-specific cells. The authors hypothesized that inducing expression of the more immunogenic latent viral antigens expressed in EBV type II and III latency tumors, such as posttransplant lymphoproliferative disease (PTLD), on EBV I latency tumors like BL, could improve the activity of virus-directed immunotherapies against these tumors.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32437562","pmcid":"PMC7243150","openalex_id":"https://openalex.org/W3026211455","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"P50 CA126752","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA125123","title":null}],"total_grants":2,"fwci":0.5322,"citation_percentile":0.65394192,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://ashpublications.org/blood/article-pdf/135/21/1822/1731366/bloodbld2020005492c.pdf","host_type":"journal"},{"url":"https://ashpublications.org/blood/article-pdf/135/21/1822/1731366/bloodbld2020005492c.pdf","host_type":"publisher"},{"url":"http://ashpublications.org/blood/article-pdf/135/21/1822/1731366/bloodbld2020005492c.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1182/blood.2020005492","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32437562","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7243150","host_type":"repository"}],"fields_of_study":["Viral-associated cancers and disorders","Lymphoma Diagnosis and Treatment","CAR-T cell therapy research","Burkitt Lymphoma","Epigenesis, Genetic","Herpesvirus 4, Human","Humans","Immunotherapy","Lymphoma"],"mesh_terms":["Burkitt Lymphoma","Herpesvirus 4, Human","Humans","Immunotherapy","Lymphoma","Epigenesis, Genetic"],"keywords":["Antigen","Decitabine","Lymphoma","Virus latency","Virus","Epstein–Barr virus","Virology","Mononucleosis","Immunology","Herpesviridae","Biology","Cancer research","Medicine","Viral disease","DNA methylation","Viral replication","Gene expression"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:33:33.514880Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}