{"doi":"10.1182/blood.2019004602","title":"Tocilizumab in patients with symptomatic Kaposi sarcoma herpesvirus–associated multicentric Castleman disease","abstract":"Kaposi sarcoma (KS) herpesvirus (KSHV), also known as human herpesvirus-8, is the causative agent for KS and a plasmablastic form of multicentric Castleman disease (MCD; KSHV-MCD). 1 KSHV-MCD is a relapsing and remitting B-cell lymphoproliferative disorder that occurs primarily in people living with HIV. 2,3Patients present with anemia, thrombocytopenia, and inflammatory symptoms associated with elevated cytokines including interleukin-6 (IL-6) and IL-10, elevated levels of C-reactive protein (CRP), and elevated KSHV viral loads (KSHV-VLs).5][6] Treatment options include rituximab (a humanized monoclonal antibody against CD20), rituximab with liposomal doxorubicin or etoposide, or virus-activated cytotoxic therapy with high-dose zidovudine (AZT) and valganciclovir (VGC). 7-13However, some patients do not respond to rituximab, and, when used alone, it is associated with worsening or development of KS in 35% to 67%. 8,9","journal":"Blood","year":2020,"id":66395,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9578,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334813,"name":"Kathryn Lurain","orcid":"0000-0002-5794-7292","position":1,"is_corresponding":false},{"id":109199,"name":"Cody J. Peer","orcid":"0000-0001-9395-3473","position":2,"is_corresponding":false},{"id":351601,"name":"Anna Serquiña","orcid":"0000-0001-5629-6099","position":3,"is_corresponding":false},{"id":351602,"name":"Victoria Wang","orcid":"0000-0003-4552-0766","position":4,"is_corresponding":false},{"id":335823,"name":"Anaida Widell","orcid":null,"position":5,"is_corresponding":false},{"id":335822,"name":"Priscila Gonçalves","orcid":null,"position":6,"is_corresponding":false},{"id":109203,"name":"Seth M. Steinberg","orcid":"0000-0002-8280-551X","position":7,"is_corresponding":false},{"id":351603,"name":"Vickie Marshall","orcid":"0000-0002-4069-185X","position":8,"is_corresponding":false},{"id":287470,"name":"Jomy George","orcid":null,"position":9,"is_corresponding":false},{"id":109200,"name":"William D. Figg","orcid":"0000-0003-2428-5613","position":10,"is_corresponding":false},{"id":351604,"name":"Denise Whitby","orcid":"0000-0002-7407-2563","position":11,"is_corresponding":false},{"id":351605,"name":"Joseph M. Ziegelbauer","orcid":"0000-0001-6464-6941","position":12,"is_corresponding":false},{"id":334814,"name":"Thomas S. Uldrick","orcid":"0000-0001-6959-0924","position":13,"is_corresponding":false},{"id":299038,"name":"Robert Yarchoan","orcid":"0000-0002-3057-1395","position":14,"is_corresponding":false},{"id":334815,"name":"Ramya Ramaswami","orcid":"0000-0001-5709-4675","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T21:14:22.090509Z","pmid":"32276276","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}