{"doi":"10.1182/blood.2019003186","title":"Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies","abstract":"Human graft-versus-host disease (GVHD) biology beyond 3 months after hematopoietic stem cell transplantation (HSCT) is complex. The Applied Biomarker in Late Effects of Childhood Cancer study (ABLE/PBMTC1202, NCT02067832) evaluated the immune profiles in chronic GVHD (cGVHD) and late acute GVHD (L-aGVHD). Peripheral blood immune cell and plasma markers were analyzed at day 100 post-HSCT and correlated with GVHD diagnosed according to the National Institutes of Health consensus criteria (NIH-CC) for cGVHD. Of 302 children enrolled, 241 were evaluable as L-aGVHD, cGVHD, active L-aGVHD or cGVHD, and no cGVHD/L-aGVHD. Significant marker differences, adjusted for major clinical factors, were defined as meeting all 3 criteria: receiver-operating characteristic area under the curve ≥0.60, P ≤ .05, and effect ratio ≥1.3 or ≤0.75. Patients with only distinctive features but determined as cGVHD by the adjudication committee (non-NIH-CC) had immune profiles similar to NIH-CC. Both cGVHD and L-aGVHD had decreased transitional B cells and increased cytolytic natural killer (NK) cells. cGVHD had additional abnormalities, with increased activated T cells, naive helper T (Th) and cytotoxic T cells, loss of CD56bright regulatory NK cells, and increased ST2 and soluble CD13. Active L-aGVHD before day 114 had additional abnormalities in naive Th, naive regulatory T (Treg) cell populations, and cytokines, and active cGVHD had an increase in PD-1- and a decrease in PD-1+ memory Treg cells. Unsupervised analysis appeared to show a progression of immune abnormalities from no cGVHD/L-aGVHD to L-aGVHD, with the most complex pattern in cGVHD. Comprehensive immune profiling will allow us to better understand how to minimize L-aGVHD and cGVHD. Further confirmation in adult and pediatric cohorts is needed.","journal":"Blood","year":2020,"id":59352,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9311,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":312096,"name":"Amina Kariminia","orcid":"0000-0003-2839-5780","position":1,"is_corresponding":false},{"id":5263,"name":"Bernard Ng","orcid":"0000-0002-8688-3873","position":2,"is_corresponding":false},{"id":312097,"name":"Sayeh Abdossamadi","orcid":"0000-0002-2873-0449","position":3,"is_corresponding":false},{"id":313188,"name":"Madeline Lauener","orcid":null,"position":4,"is_corresponding":false},{"id":312098,"name":"Eneida R. Nemecek","orcid":"0000-0003-1522-8924","position":5,"is_corresponding":false},{"id":37044,"name":"Justin T. Wahlstrom","orcid":"0000-0001-7998-8506","position":6,"is_corresponding":false},{"id":312099,"name":"Carrie L. Kitko","orcid":"0000-0001-9216-2901","position":7,"is_corresponding":false},{"id":312100,"name":"Victor Lewis","orcid":"0000-0001-6513-8586","position":8,"is_corresponding":false},{"id":312101,"name":"Tal Schechter","orcid":"0009-0004-5844-164X","position":9,"is_corresponding":false},{"id":312102,"name":"David A. Jacobsohn","orcid":"0000-0001-6119-3270","position":10,"is_corresponding":false},{"id":312103,"name":"Andrew C. Harris","orcid":"0000-0002-4538-8817","position":11,"is_corresponding":false},{"id":263463,"name":"Michael A. Pulsipher","orcid":"0000-0003-3030-8420","position":12,"is_corresponding":false},{"id":312104,"name":"Henrique Bittencourt","orcid":"0000-0002-5507-8310","position":13,"is_corresponding":false},{"id":289202,"name":"Sung Won Choi","orcid":"0000-0002-6321-3834","position":14,"is_corresponding":false},{"id":295463,"name":"Emi Caywood","orcid":"0000-0002-2873-6058","position":15,"is_corresponding":false},{"id":312105,"name":"Kimberly A. Kasow","orcid":"0000-0002-0651-8666","position":16,"is_corresponding":false},{"id":295460,"name":"Monica Bhatia","orcid":"0009-0002-9110-4632","position":17,"is_corresponding":false},{"id":295457,"name":"Benjamin Oshrine","orcid":"0000-0002-2836-2244","position":18,"is_corresponding":false},{"id":313189,"name":"Allyson Flower","orcid":null,"position":19,"is_corresponding":false},{"id":263438,"name":"Sonali Chaudhury","orcid":"0000-0001-9816-5126","position":20,"is_corresponding":false},{"id":312106,"name":"Donald W. Coulter","orcid":"0000-0002-7829-0971","position":21,"is_corresponding":false},{"id":312107,"name":"Joseph H. Chewning","orcid":"0000-0001-5554-5890","position":22,"is_corresponding":false},{"id":280631,"name":"Michael Joyce","orcid":"0009-0000-1253-1472","position":23,"is_corresponding":false},{"id":312108,"name":"Süreyya Savaşan","orcid":"0000-0001-7138-3027","position":24,"is_corresponding":false},{"id":312109,"name":"Anna Pawłowska","orcid":"0000-0001-9466-6396","position":25,"is_corresponding":false},{"id":313190,"name":"Gail Megason","orcid":null,"position":26,"is_corresponding":false},{"id":313191,"name":"David Mitchell","orcid":null,"position":27,"is_corresponding":false},{"id":312110,"name":"Alexandra Cheerva","orcid":"0000-0002-6494-1817","position":28,"is_corresponding":false},{"id":312111,"name":"Ánita Lawitschka","orcid":"0000-0002-4843-4735","position":29,"is_corresponding":false},{"id":312112,"name":"Shima Azadpour","orcid":"0000-0003-0152-3287","position":30,"is_corresponding":false},{"id":312113,"name":"Elena Ostroumov","orcid":"0000-0002-1799-1053","position":31,"is_corresponding":false},{"id":312114,"name":"Peter Subrt","orcid":"0000-0001-7370-3397","position":32,"is_corresponding":false},{"id":312115,"name":"Anat Halevy","orcid":"0000-0002-0212-8433","position":33,"is_corresponding":false},{"id":5261,"name":"Sara Mostafavi","orcid":"0000-0003-4698-1177","position":34,"is_corresponding":false},{"id":263461,"name":"Geoff D.E. Cuvelier","orcid":"0000-0003-4493-8757","position":35,"is_corresponding":false},{"id":312095,"name":"Kirk R. Schultz","orcid":"0000-0002-0001-6438","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32047896","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}