{"doi":"10.1182/blood.2019002334","title":"Assessment of ST2 for risk of death following graft-versus-host disease in pediatric and adult age groups","abstract":"Assessment of prognostic biomarkers of nonrelapse mortality (NRM) after allogeneic hematopoietic cell transplantation (HCT) in the pediatric age group is lacking. To address this need, we conducted a prospective cohort study with 415 patients at 6 centers: 170 were children age 10 years or younger and 245 were patients older than age 10 years (both children and adults were accrued from 2013 to 2018). The following 4 plasma biomarkers were assessed pre-HCT and at days +7, +14, and +21 post-HCT: stimulation-2 (ST2), tumor necrosis factor receptor 1 (TNFR1), regenerating islet-derived protein 3α (REG3α), and interleukin-6 (IL-6). We performed landmark analyses for NRM, dichotomizing the cohort at age 10 years or younger and using each biomarker median as a cutoff for high- and low-risk groups. Post-HCT biomarker analysis showed that ST2 (>26 ng/mL), TNFR1 (>3441 pg/mL), and REG3α (>25 ng/mL) are associated with NRM in children age 10 years or younger (ST2: hazard ratio [HR], 9.13; 95% confidence interval [CI], 2.74-30.38; P = .0003; TNFR1: HR, 4.29; 95% CI, 1.48-12.48; P = .0073; REG3α: HR, 7.28; 95% CI, 2.05-25.93; P = .0022); and in children and adults older than age 10 years (ST2: HR, 2.60; 95% CI, 1.15-5.86; P = .021; TNFR1: HR, 2.09; 95% CI, 0.96-4.58; P = .06; and REG3α: HR, 2.57; 95% CI, 1.19-5.55; P = .016). When pre-HCT biomarkers were included, only ST2 remained significant in both cohorts. After adjustment for significant covariates (race/ethnicity, malignant disease, graft, and graft-versus-host-disease prophylaxis), ST2 remained associated with NRM only in recipients age 10 years or younger (HR, 4.82; 95% CI, 1.89-14.66; P = .0056). Assays of ST2, TNFR1, and REG3α in the first 3 weeks after HCT have prognostic value for NRM in both children and adults. The presence of ST2 before HCT is a prognostic biomarker for NRM in children age 10 years or younger allowing for additional stratification. This trial was registered at www.clinicaltrials.gov as #NCT02194439.","journal":"Blood","year":2020,"id":76644,"datarank":0.8687839109710533,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.4121055453125399,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.4121055453125399,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":13,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8949,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02194439"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296874,"name":"Francis Pike","orcid":null,"position":1,"is_corresponding":false},{"id":259086,"name":"Kenneth R. Cooke","orcid":"0000-0002-0275-6931","position":2,"is_corresponding":false},{"id":399682,"name":"Robert A. Krance","orcid":"0000-0001-7643-6933","position":3,"is_corresponding":false},{"id":371659,"name":"Paul A. Carpenter","orcid":"0000-0002-5021-0714","position":4,"is_corresponding":false},{"id":399683,"name":"Christine Duncan","orcid":"0000-0002-2090-4897","position":5,"is_corresponding":false},{"id":312102,"name":"David A. Jacobsohn","orcid":"0000-0001-6119-3270","position":6,"is_corresponding":false},{"id":263322,"name":"Catherine M. Bollard","orcid":"0000-0001-5140-9090","position":7,"is_corresponding":false},{"id":263320,"name":"Carolina Colli Cruz","orcid":"0000-0001-7065-3769","position":8,"is_corresponding":false},{"id":399684,"name":"Abhijeet Malatpure","orcid":"0000-0003-3232-2269","position":9,"is_corresponding":false},{"id":12595,"name":"Sherif S. Farag","orcid":"0000-0002-3088-843X","position":10,"is_corresponding":false},{"id":397107,"name":"Jamie L. Renbarger","orcid":"0000-0001-9629-8216","position":11,"is_corresponding":false},{"id":399685,"name":"Hao Liu","orcid":"0000-0003-0356-7478","position":12,"is_corresponding":false},{"id":399686,"name":"Giorgos Bakoyannis","orcid":"0000-0002-2789-2497","position":13,"is_corresponding":false},{"id":57918,"name":"Samir Hanash","orcid":"0000-0002-4210-1593","position":14,"is_corresponding":false},{"id":348770,"name":"Sophie Paczesny","orcid":"0000-0001-5571-2775","position":15,"is_corresponding":false},{"id":333680,"name":"Courtney M. Rowan","orcid":"0000-0003-1393-6476","position":0,"is_corresponding":true}],"reference_count":34,"raw_metadata":null,"created_at":"2026-07-18T21:48:27.511277Z","pmid":"31972009","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}