{"doi":"10.1177/2474126420936199","title":"Quantifying Subclinical and Longitudinal Microvascular Changes Following Episcleral Plaque Brachytherapy Using Spectral Domain–Optical Coherence Tomography Angiography","abstract":"Purpose: This work assesses longitudinal microvascular changes in eyes treated with iodine-125 episcleral plaque brachytherapy (EPB). Methods: High-resolution optical coherence tomography angiograms (OCTAs) of the central 3 × 3-mm macula were obtained from iodine-125 EPB–treated and untreated fellow eyes of 61 patients. Previously validated semiautomated algorithms quantified capillary density (vessel skeleton density [VSD]) and caliber (vessel diameter index). Nonperfusion was also quantified as flow impairment region (FIR). Examinations from treated and fellow eyes obtained before treatment and at 6-month, 1-year, and 2-year intervals were compared using generalized estimating equation linear models. Dosimetry maps evaluated spatial correlation between radiation dose and microvascular metrics. Results: At 6 months, treated eyes had significantly lower VSD (0.145 ± 0.003 vs 0.155 ± 0.002; P = .009) and higher FIR (2.01 ± 0.199 vs 1.46 ± 0.104; P = .01) compared with fellow eyes. There was a significant decrease in VSD and a corresponding increase in FIR even for treated eyes without clinically identifiable retinopathy at 6 months. Vessel diameter index was significantly higher in treated eyes than in fellow eyes at 2 years (2.92 ± 0.025 vs 2.84 ± 0.018; P < .001). We categorized our cohort into low-dose (< 15 Gy) and high-dose (> 45 Gy) radiation to the fovea and noted significant differences in VSD and FIR between groups. Conclusions: OCTA can quantify and monitor EPB-induced retinopathy and can detect vascular abnormalities even without clinically observable retinopathy. OCTA may be useful in investigating treatment interventions aiming to delay EPB-induced radiation retinopathy.","journal":"Journal of VitreoRetinal Diseases","year":2020,"id":72567,"datarank":0.42498200160843247,"base_score":2.833213344056216,"endowment":2.833213344056216,"self_citation_contribution":0.42498200160843247,"citation_network_contribution":0.0,"self_endowment_contribution":0.42498200160843247,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7388,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":382735,"name":"Brian C. Toy","orcid":"0000-0002-9612-5697","position":1,"is_corresponding":false},{"id":382736,"name":"Bright S. Ashimatey","orcid":"0000-0002-1319-1008","position":2,"is_corresponding":false},{"id":382737,"name":"Debarshi Mustafi","orcid":"0000-0002-9164-7488","position":3,"is_corresponding":false},{"id":362769,"name":"R. Jennelle","orcid":null,"position":4,"is_corresponding":false},{"id":382738,"name":"Melvin A. Astrahan","orcid":"0000-0003-3062-4335","position":5,"is_corresponding":false},{"id":382739,"name":"Zhongdi Chu","orcid":"0000-0001-7430-5032","position":6,"is_corresponding":false},{"id":284472,"name":"Ruikang K. Wang","orcid":"0000-0001-5169-8822","position":7,"is_corresponding":false},{"id":382740,"name":"Jonathan Kim","orcid":"0000-0001-5817-348X","position":8,"is_corresponding":false},{"id":317496,"name":"Jesse L. Berry","orcid":"0000-0002-8907-9100","position":9,"is_corresponding":false},{"id":382741,"name":"Amir H. Kashani","orcid":"0000-0001-9767-7920","position":10,"is_corresponding":false},{"id":384108,"name":"Kyle M. Green","orcid":null,"position":0,"is_corresponding":true}],"reference_count":30,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:45:09.279825Z","pmid":"33409441","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}