{"doi":"10.1177/23969873241241885","title":"Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:</jats:title>\n                    <jats:p>Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:</jats:title>\n                    <jats:p>This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p &amp;lt; 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p &amp;lt; 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p &amp;lt; 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.</jats:p>\n                  </jats:sec>","journal":"European Stroke Journal","year":2024,"id":616180,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1149304,"name":"Anita van de Munckhof","orcid":"0000-0001-6028-3426","position":1,"is_corresponding":false},{"id":1588502,"name":"Angel T. Miraclin","orcid":null,"position":2,"is_corresponding":false},{"id":1588503,"name":"Sanjith Aaron","orcid":null,"position":3,"is_corresponding":false},{"id":1571966,"name":"Sajid Hameed","orcid":null,"position":4,"is_corresponding":false},{"id":1277996,"name":"Mohammad Wasay","orcid":"0000-0003-3750-2613","position":5,"is_corresponding":false},{"id":1588506,"name":"Oxana Grosu","orcid":null,"position":6,"is_corresponding":false},{"id":1149305,"name":"Katarzyna Krzywicka","orcid":"0000-0002-9478-0401","position":7,"is_corresponding":false},{"id":1149306,"name":"Mayte Sánchez van Kammen","orcid":"0000-0001-5614-9689","position":8,"is_corresponding":false},{"id":745085,"name":"Erik Lindgren","orcid":"0000-0002-7628-5044","position":9,"is_corresponding":false},{"id":467684,"name":"Tiago Moreira","orcid":"0000-0003-3817-7103","position":10,"is_corresponding":false},{"id":1149337,"name":"Roberto Acampora","orcid":"0000-0002-9617-2821","position":11,"is_corresponding":false},{"id":1588511,"name":"Alberto Negro","orcid":null,"position":12,"is_corresponding":false},{"id":1149340,"name":"Theodoros Karapanayiotides","orcid":"0000-0002-2357-7967","position":13,"is_corresponding":false},{"id":108616,"name":"Shadi Yaghi","orcid":"0000-0003-0031-1004","position":14,"is_corresponding":false},{"id":1588517,"name":"Anna Revert","orcid":null,"position":15,"is_corresponding":false},{"id":1588519,"name":"Elisa Cuadrado Godia","orcid":null,"position":16,"is_corresponding":false},{"id":1588520,"name":"Sebastian Garcia-Madrona","orcid":null,"position":17,"is_corresponding":false},{"id":1588522,"name":"Paolino La Spina","orcid":null,"position":18,"is_corresponding":false},{"id":1149320,"name":"Francesco Grillo","orcid":"0000-0003-3160-7844","position":19,"is_corresponding":false},{"id":1149319,"name":"Fabrizio Giammello","orcid":"0000-0002-2828-1305","position":20,"is_corresponding":false},{"id":620423,"name":"Thanh N. Nguyen","orcid":"0000-0002-2810-1685","position":21,"is_corresponding":false},{"id":620424,"name":"Mohamad Abdalkader","orcid":"0000-0002-9528-301X","position":22,"is_corresponding":false},{"id":1588524,"name":"Alina Buture","orcid":null,"position":23,"is_corresponding":false},{"id":617524,"name":"Maria Sofia Cotelli","orcid":"0000-0002-7010-2809","position":24,"is_corresponding":false},{"id":679709,"name":"Nicolas Raposo","orcid":"0000-0002-9152-4445","position":25,"is_corresponding":false},{"id":297808,"name":"Georgios Tsivgoulis","orcid":"0000-0002-0640-3797","position":26,"is_corresponding":false},{"id":1149336,"name":"Paolo Candelaresi","orcid":"0000-0003-2477-840X","position":27,"is_corresponding":false},{"id":1588525,"name":"Antonio Ciacciarelli","orcid":"0000-0003-3282-4672","position":28,"is_corresponding":false},{"id":1149323,"name":"Joshua Mbroh","orcid":"0000-0002-0108-9161","position":29,"is_corresponding":false},{"id":1588526,"name":"Tatiana Batenkova","orcid":"0009-0003-5058-063X","position":30,"is_corresponding":false},{"id":1588527,"name":"Pasquale Scoppettuolo","orcid":null,"position":31,"is_corresponding":false},{"id":112962,"name":"Marialuisa Zedde","orcid":"0000-0001-7530-818X","position":32,"is_corresponding":false},{"id":112963,"name":"Rosario Pascarella","orcid":null,"position":33,"is_corresponding":false},{"id":1588528,"name":"Kateryna Antonenko","orcid":null,"position":34,"is_corresponding":false},{"id":493520,"name":"Espen Saxhaug Kristoffersen","orcid":"0000-0002-8999-5424","position":35,"is_corresponding":false},{"id":794985,"name":"Johanna A. Kremer Hovinga","orcid":"0000-0002-1300-7135","position":36,"is_corresponding":false},{"id":297807,"name":"Katarina Jood","orcid":"0000-0001-8746-1771","position":37,"is_corresponding":false},{"id":627676,"name":"Diana Aguiar de Sousa","orcid":"0000-0002-6702-7924","position":38,"is_corresponding":false},{"id":674263,"name":"Sven Poli","orcid":"0000-0002-0286-8781","position":39,"is_corresponding":false},{"id":297818,"name":"Turgut Tatlisumak","orcid":"0000-0002-2430-8988","position":40,"is_corresponding":false},{"id":745089,"name":"Jukka Putaala","orcid":"0000-0002-6630-6104","position":41,"is_corresponding":false},{"id":591989,"name":"Jonathan M. Coutinho","orcid":"0000-0002-8284-982X","position":42,"is_corresponding":false},{"id":58219,"name":"José M. Ferro","orcid":"0000-0002-2343-9097","position":43,"is_corresponding":false},{"id":841249,"name":"Marcel Arnold","orcid":"0000-0002-4274-4644","position":44,"is_corresponding":false},{"id":1149343,"name":"Mirjam R. Heldner","orcid":"0000-0002-3594-2159","position":45,"is_corresponding":false},{"id":113996,"name":"Adrian Scutelnic","orcid":"0000-0001-9053-584X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:</jats:title>\n                    <jats:p>Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods:</jats:title>\n                    <jats:p>This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p &amp;lt; 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p &amp;lt; 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p &amp;lt; 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38572798","pmcid":"PMC11418515","openalex_id":"https://openalex.org/W4393934947","authors":[],"funders":[],"total_grants":0,"fwci":2.7153,"citation_percentile":0.90641185,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":5},{"year":2026,"count":3}],"oa_status":"bronze","license":"https://academic.oup.com/pages/standard-publication-reuse-rights","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/23969873241241885","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/23969873241241885","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1177/23969873241241885","host_type":"publisher"},{"url":"https://academic.oup.com/esj/article-pdf/9/3/676/64653618/23969873241241885.pdf","host_type":"publisher"},{"url":"https://doi.org/10.1177/23969873241241885","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38572798","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11418515","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/en/publications/739bc734-2dd9-43ca-bac9-0440b5602b1f","host_type":"repository"},{"url":"https://ecommons.aku.edu/pakistan_fhs_mc_med_neurol/265","host_type":"repository"},{"url":"https://boris.unibe.ch/195679/","host_type":"repository"},{"url":"http://hdl.handle.net/2078.1/300517","host_type":"repository"},{"url":"https://hdl.handle.net/11573/1741979","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11418515/pdf/10.1177_23969873241241885.pdf","host_type":"repository"},{"url":"https://pure.amsterdamumc.nl/ws/files/136888390/Characteristics-and-outcomes-of-cerebral-venous-thrombosis-associated-with-covid-19.pdf","host_type":"repository"}],"fields_of_study":["Cerebral Venous Sinus Thrombosis","Long-Term Effects of COVID-19","COVID-19 Clinical Research Studies","Humans","COVID-19","Female","Male","Middle Aged","Intracranial Thrombosis","Venous Thrombosis","Registries","Adult","Aged","Length of Stay","SARS-CoV-2","Hospital Mortality"],"mesh_terms":["COVID-19","SARS-CoV-2","Adult","Aged","Female","Humans","Length of Stay","Male","Middle Aged","Registries","Hospital Mortality","Venous Thrombosis","Intracranial Thrombosis"],"keywords":["Medicine","Coronavirus disease 2019 (COVID-19)","Modified Rankin Scale","Venous thrombosis","Internal medicine","Thrombosis","Cohort","Thrombus","Confidence interval","Disease","Ischemic stroke","Ischemia","Stroke","Cerebral Venous Thrombosis","Covid-19"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T22:13:04.940764Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}