{"doi":"10.1177/2329048x231225916","title":"“Oh My Sleeping Child” … Narcolepsy Type 1 in a 22-Month-Old Boy","abstract":"<jats:p>Pediatric narcolepsy is a complex disorder with unique diagnostic challenges. It is diagnosed with a combination of clinical presentation, polysomnogram with multiple sleep latency test (PSG with MSLT), and occasionally, hypocretin-1 (orexin) levels in the cerebrospinal fluid (CSF). This report describes a 22-month-old boy experiencing excessive daytime sleepiness (EDS) and frequent falls. The patient was subsequently diagnosed with narcolepsy using hypocretin-1 (orexin) levels. The intent of this report is to establish the utility of using hypocretin-1 (orexin) levels to diagnose narcolepsy type 1 in children who are too young to undergo PSG with MSLT. To our knowledge, there are no reports of narcolepsy in a patient this young. Early recognition and treatment of narcolepsy in children younger than age five may lead to a substantial impact on their cognitive development and minimize potential long- term complications.</jats:p>","journal":"Child Neurology Open","year":2024,"id":675613,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":302331,"name":"Alexandra Morgan","orcid":"0000-0001-7787-0547","position":1,"is_corresponding":false},{"id":250761,"name":"Sonal Bhatia","orcid":"0000-0001-9735-4304","position":2,"is_corresponding":false},{"id":1478418,"name":"Barbra Giourgas","orcid":"0000-0003-0364-1690","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"“Oh My Sleeping Child” … Narcolepsy Type 1 in a 22-Month-Old Boy","abstract":"<jats:p>Pediatric narcolepsy is a complex disorder with unique diagnostic challenges. It is diagnosed with a combination of clinical presentation, polysomnogram with multiple sleep latency test (PSG with MSLT), and occasionally, hypocretin-1 (orexin) levels in the cerebrospinal fluid (CSF). This report describes a 22-month-old boy experiencing excessive daytime sleepiness (EDS) and frequent falls. The patient was subsequently diagnosed with narcolepsy using hypocretin-1 (orexin) levels. The intent of this report is to establish the utility of using hypocretin-1 (orexin) levels to diagnose narcolepsy type 1 in children who are too young to undergo PSG with MSLT. To our knowledge, there are no reports of narcolepsy in a patient this young. Early recognition and treatment of narcolepsy in children younger than age five may lead to a substantial impact on their cognitive development and minimize potential long- term complications.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38766557","pmcid":"PMC11097692","openalex_id":"https://openalex.org/W4390730251","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00516221,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by-nc","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/2329048X231225916","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/2329048X231225916","host_type":"publisher"},{"url":"http://journals.sagepub.com/doi/pdf/10.1177/2329048X231225916","host_type":"publisher"},{"url":"http://journals.sagepub.com/doi/full-xml/10.1177/2329048X231225916","host_type":"publisher"},{"url":"https://doi.org/10.1177/2329048x231225916","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38766557","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11097692","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11097692/pdf/10.1177_2329048X231225916.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11097692","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11097692?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Sleep and Wakefulness Research","Sleep and related disorders","Restless Legs Syndrome Research"],"mesh_terms":[],"keywords":["Narcolepsy","Polysomnogram","Orexin","Multiple Sleep Latency Test","Excessive daytime sleepiness","Pediatrics","Cataplexy","Medicine","Neurology","Sleep disorder","Psychology","Psychiatry","Internal medicine","Cognition","Polysomnography","Apnea","Neuropeptide","Toddler","Pediatric Narcolepsy","Hypocretin-1(orexin)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:28:08.899216Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}