{"doi":"10.1177/21677026241305377","title":"Introducing the Glutamate-Amplifies-Noradrenergic-Effects (GANE) Model to the Neurocognitive Study of Emotion-Related Impulsivity","abstract":"Emotion-related impulsivity (ERI) shows robust longitudinal associations with psychiatric disorders, aggression, and suicidality, yet a parsimonious account of its neurocognitive correlates has not been offered. We connect ERI with the glutamate-amplifies-noradrenergic-effects (GANE) model, a framework describing how norepinephrine tunes “hotspots” of brain activation during heightened physiological arousal. First, we systematically reviewed studies of ERI and task-based functional MRI. Meta-analysis of significant effects yielded one cluster in right inferior frontal gyrus. Twenty-six of 30 significant effects systematically colocalized in neuroanatomical hotspots in each corresponding task, in line with GANE. Second, adults recruited for a range of psychopathology ( N = 120) completed a reward/punishment go/no-go task while undergoing functional MRI. ERI correlated with stronger nucleus-accumbens activation for a model sensitive to heightened trial reward and in anterior cingulate for models sensitive to heightened trial arousal. Findings provide empirical support for the relevance of GANE hotspot mechanisms to ERI.","journal":"Clinical Psychological Science","year":2025,"id":540385,"datarank":0.17141178828309234,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.006619944982875882,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.006619944982875882,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9581,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":989231,"name":"Ming Hsu","orcid":"0000-0001-7195-3579","position":1,"is_corresponding":false},{"id":490353,"name":"Lucina Q. Uddin","orcid":"0000-0003-2278-8962","position":2,"is_corresponding":false},{"id":1428170,"name":"Kiana Modavi","orcid":"0000-0002-6261-197X","position":3,"is_corresponding":false},{"id":519437,"name":"Sheri L. Johnson","orcid":"0000-0002-9945-4816","position":4,"is_corresponding":false},{"id":56810,"name":"Matthew Elliott","orcid":"0000-0001-9519-0318","position":0,"is_corresponding":true}],"reference_count":130,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:52:38.861025Z","pmid":"40766340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}