{"doi":"10.1177/21501319251348099","title":"Adherence to Repeat Screening Completion for Colorectal Cancer Using the Multi-Target Stool DNA Test: Real-World Analysis of Patients from Federally Qualified Health Centers","abstract":"<jats:sec>\n                    <jats:title>Introduction/Objectives:</jats:title>\n                    <jats:p>This real-world study examined adherence to repeat mt-sDNA among patients from federally qualified health centers (FQHCs) across the US and among different payer types.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>Data from Exact Sciences Laboratories, LLC were used for the period between January 1, 2023, and December 31, 2023, for those who had previously completed a mt-sDNA test. Study outcomes included adherence rate to mt-sDNA repeat screening and time to test return.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      The study sample consisted of 19 536 eligible patients. The mt-sDNA repeat screening adherence rate was 79.7%, and the mean time to return the kit was 21.1 ± 20.8 days. Repeat screening adherence for patients with Medicare was 84.7%, Medicare Advantage was 80%, commercial insurance was 78.2%, managed care organization was 74.6%, and Medicaid was 65.9% (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                       &lt; .001). Compared with patients covered by commercial insurance, those covered by Medicaid had 42% lower odds of adhering to mt-sDNA repeat screening. Patients with 2 or more prior successful tests had a numerically shorter mean time to test return compared to those with only 1 prior successful test.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>While repeat screening adherence was generally high across patient demographic categories, there were significant differences by type of insurance coverage and number of prior successful mt-sDNA screenings.</jats:p>\n                  </jats:sec>","journal":"Journal of Primary Care &amp; Community Health","year":2025,"id":644513,"datarank":0.3813227792277796,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.06940654797580414,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.06940654797580414,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1677632,"name":"Timo Pew","orcid":null,"position":1,"is_corresponding":false},{"id":1677634,"name":"Jorge Zapatier","orcid":null,"position":2,"is_corresponding":false},{"id":1677635,"name":"Juliana Vanessa Rincón López","orcid":null,"position":3,"is_corresponding":false},{"id":1677636,"name":"Paul Limburg","orcid":null,"position":4,"is_corresponding":false},{"id":1677637,"name":"Martha Duarte","orcid":null,"position":5,"is_corresponding":false},{"id":1677631,"name":"Mallik Greene","orcid":"0000-0001-9363-5483","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adherence to Repeat Screening Completion for Colorectal Cancer Using the Multi-Target Stool DNA Test: Real-World Analysis of Patients from Federally Qualified Health Centers","abstract":"<jats:sec>\n                    <jats:title>Introduction/Objectives:</jats:title>\n                    <jats:p>This real-world study examined adherence to repeat mt-sDNA among patients from federally qualified health centers (FQHCs) across the US and among different payer types.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:</jats:title>\n                    <jats:p>Data from Exact Sciences Laboratories, LLC were used for the period between January 1, 2023, and December 31, 2023, for those who had previously completed a mt-sDNA test. Study outcomes included adherence rate to mt-sDNA repeat screening and time to test return.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      The study sample consisted of 19 536 eligible patients. The mt-sDNA repeat screening adherence rate was 79.7%, and the mean time to return the kit was 21.1 ± 20.8 days. Repeat screening adherence for patients with Medicare was 84.7%, Medicare Advantage was 80%, commercial insurance was 78.2%, managed care organization was 74.6%, and Medicaid was 65.9% (\n                      <jats:italic toggle=\"yes\">P</jats:italic>\n                       &lt; .001). Compared with patients covered by commercial insurance, those covered by Medicaid had 42% lower odds of adhering to mt-sDNA repeat screening. Patients with 2 or more prior successful tests had a numerically shorter mean time to test return compared to those with only 1 prior successful test.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>While repeat screening adherence was generally high across patient demographic categories, there were significant differences by type of insurance coverage and number of prior successful mt-sDNA screenings.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40528162","pmcid":"PMC12174683","openalex_id":null,"authors":[],"funders":[{"funder_name":"Exact Sciences Corporation","grant_id":"","title":null}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://doi.org/10.1177/21501319251348099","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/21501319251348099","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1177/21501319251348099","host_type":"publisher"},{"url":"https://doaj.org/article/9006f656edeb492a8771a763b94e5d04","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12174683","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12174683","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12174683?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Feces","Humans","Colorectal Neoplasms","DNA","Patient Compliance","Aged","Middle Aged","Medicaid","Medicare","United States","Female","Male","Early Detection of Cancer"],"keywords":["Adherence","Colon cancer","Repeat Screening","Mt-sdna","Stool-based Tests"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:19:22.821722Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}