{"doi":"10.1177/20499361241272630","title":"Prevalence and factors associated with hyperglycemia among persons living with HIV/AIDS on dolutegravir-based antiretroviral therapy in Uganda","abstract":"Background: Dolutegravir-based (DTG) regimens are rapidly becoming the preferred first-line antiretroviral therapy (ART) for people living with HIV (PLHIV) in low and middle-income countries. However, there are rising concerns over the development of hyperglycemia and, in some cases, diabetes mellitus in patients switched to DTG. Objectives: To determine the prevalence and factors associated with hyperglycemia among PLHIV receiving DTG-based ART at Kiruddu National Referral Hospital (KNRH), Uganda. Design: Cross-sectional study. Methods: The study was conducted in the inpatient wards and the infectious disease outpatient clinic of KNRH from May to July 2022. Participants aged ⩾18 years on a DTG-based ART regimen for at least 3 months were consecutively enrolled and interviewed using a research assistant administered questionnaire for sociodemographic and clinical characteristics. HbA1c was measured using whole blood Architect Ci4100 ® (Abbott, Illinois, USA), with hyperglycemia defined using a cut-off of ⩾5.7% as per the Uganda Diabetes Association guidelines. Factors associated with hyperglycemia were examined through logistic regression, adjusting for pertinent confounders, in STATA 17. A significance level was set at p < 0.05. Results: A total of 398 PLHIV with a median age of 40.5 years (IQR: 32–49) were enrolled. More than half were females (58.3%, n = 232) and the majority (90%) had a CD4 count above 200 cells/µL. About 16% had a family history of diabetes, 11.73% ( n = 46) showed elevated blood pressure levels, and 16.7% ( n = 64) had obesity. Hyperglycemia was present in 12.8% ( n = 51), with 10.3% having pre-diabetes ( n = 41) and 2.5% with diabetes mellitus ( n = 10). At bivariate analysis, hyperglycemia was significantly associated with age >40 years ( p < 0.001), herbal medicine use ( p = 0.03), being widowed ( p < 0.001), obesity ( p = 0.042), hypertension ( p = 0.002) and >3 since diagnosis with HIV ( p = 0.030). At multivariable regression, only age >40 (AOR 2.55, 95% CI: 1.05–6.23, p = 0.039) and hypertension (AOR 2.93, 95% CI: 1.07–8.02, p = 0.036) remained significantly associated with hyperglycemia. Conclusion: More than 1 in 10 patients on DTG-based ART in our study had hyperglycemia. We recommend regular monitoring of plasma glucose, especially for patients >40 years old and those with other comorbidities, before starting/switching to DTG regimens. Longitudinal studies are recommended to determine the underlying mechanisms of hyperglycemia in this population.","journal":"Therapeutic Advances in Infectious Disease","year":2024,"id":441104,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":546622,"name":"Ronald Olum","orcid":"0000-0003-1289-0111","position":1,"is_corresponding":false},{"id":910584,"name":"Edrisa Mutebi","orcid":null,"position":2,"is_corresponding":false},{"id":364007,"name":"Robert Kalyesubula","orcid":"0000-0003-3211-163X","position":3,"is_corresponding":false},{"id":1254159,"name":"Majid Kagimu","orcid":null,"position":4,"is_corresponding":false},{"id":397657,"name":"David B. Meya","orcid":"0000-0002-8854-0321","position":5,"is_corresponding":false},{"id":363348,"name":"Irene Andia Biraro","orcid":"0000-0002-8303-6046","position":6,"is_corresponding":false},{"id":1253542,"name":"Lillian Happy Byereta","orcid":"0009-0002-1160-8591","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:01:06.281460Z","pmid":"39286262","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}