{"doi":"10.1177/2045894020966547","title":"Circulating markers of angiogenesis and endotheliopathy in COVID‐19","abstract":"Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID-19 infection. While endotheliopathy is thought to be a key factor of COVID-19-associated coagulopathy, markers indicative of this process that are prognostic of disease severity have not been well-established in this patient population. Using plasma profiling of patients with COVID-19, we identified circulating markers that segregated with disease severity: markers of angiogenesis (VEGF-A, PDGF-AA and PDGF-AB/BB) were elevated in hospitalized patients with non-critical COVID-19 infection, while markers of endothelial injury (angiopoietin-2, FLT-3L, PAI-1) were elevated in patients with critical COVID-19 infection. In survival analysis, elevated markers of endothelial injury (angiopoietin-2, follistatin, PAI-1) were strongly predictive of in-hospital mortality. Our findings demonstrate that non-critical and critical phases of COVID-19 disease may be driven by distinct mechanisms involving key aspects of endothelial cell function, and identify drivers of COVID-19 pathogenesis and potential targets for future therapies.","journal":"Pulmonary Circulation","year":2020,"id":51475,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":106664,"name":"Matthew L. Meizlish","orcid":"0000-0002-4306-5061","position":1,"is_corresponding":false},{"id":106662,"name":"George Goshua","orcid":"0000-0002-1624-4427","position":2,"is_corresponding":false},{"id":106665,"name":"C‐Hong Chang","orcid":null,"position":3,"is_corresponding":false},{"id":106666,"name":"Hanming Zhang","orcid":"0000-0002-5992-5433","position":4,"is_corresponding":false},{"id":256671,"name":"Jason Bishai","orcid":"0000-0002-9526-0483","position":5,"is_corresponding":false},{"id":106667,"name":"Parveen Bahel","orcid":null,"position":6,"is_corresponding":false},{"id":256672,"name":"Amisha Patel","orcid":"0009-0007-0869-2768","position":7,"is_corresponding":false},{"id":250249,"name":"Rana Gbyli","orcid":"0000-0001-5524-0739","position":8,"is_corresponding":false},{"id":228515,"name":"Jennifer M. Kwan","orcid":"0000-0002-4715-1848","position":9,"is_corresponding":false},{"id":256673,"name":"Christine Won","orcid":"0000-0002-8568-8849","position":10,"is_corresponding":false},{"id":106677,"name":"Christina Price","orcid":"0000-0002-0200-8845","position":11,"is_corresponding":false},{"id":105837,"name":"Charles S. Dela Cruz","orcid":"0000-0002-5258-1797","position":12,"is_corresponding":false},{"id":102751,"name":"Stephanie Halene","orcid":"0000-0002-2737-9810","position":13,"is_corresponding":false},{"id":107019,"name":"David van Dijk","orcid":"0000-0003-3911-9925","position":14,"is_corresponding":false},{"id":106673,"name":"John Hwa","orcid":"0000-0001-7366-2628","position":15,"is_corresponding":false},{"id":106682,"name":"Alfred Ian Lee","orcid":"0000-0002-5968-3948","position":16,"is_corresponding":false},{"id":106681,"name":"Hyung J. Chun","orcid":"0000-0003-3508-2678","position":17,"is_corresponding":false},{"id":106663,"name":"Alexander B. Pine","orcid":"0000-0002-9463-3022","position":0,"is_corresponding":true}],"reference_count":6,"raw_metadata":null,"created_at":"2026-07-18T20:40:28.278215Z","pmid":"33282193","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}