{"doi":"10.1177/2045894018783735","title":"Crosstalk signaling between alveoli and capillaries","abstract":"<jats:p>Crosstalk signaling between the closely juxtaposed epithelial and endothelial membranes of pulmonary alveoli establishes the lung’s immune defense against inhaled and blood‐borne pathogens. The crosstalk can occur in a forward direction, as from alveolus to capillary, or in a reverse direction, as from capillary to alveolus. The crosstalk direction likely depends on the site at which pathogens first initiate signaling. Thus, forward crosstalk may occur when inhaled pathogens encounter the alveolar epithelium, while reverse crosstalk may result from interactions of blood‐borne pathogens with the endothelium. Here, we review the factors that regulate these two directions of signaling.</jats:p>","journal":"Pulmonary Circulation","year":2018,"id":631158,"datarank":0.48283137373023016,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"self_citation_contribution":0.48283137373023016,"citation_network_contribution":0.0,"self_endowment_contribution":0.48283137373023016,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":24,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316999,"name":"Sunita Bhattacharya","orcid":"0000-0002-2476-1280","position":1,"is_corresponding":false},{"id":316998,"name":"Jahar Bhattacharya","orcid":"0000-0002-5588-6211","position":2,"is_corresponding":false},{"id":1246003,"name":"Rebecca F. 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Here, we review the factors that regulate these two directions of signaling.</jats:p>","is_dataset_classified":null,"base_score":3.2188758248682006,"endowment":3.2188758248682006,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29869931","pmcid":"PMC6024290","openalex_id":"https://openalex.org/W2807571008","authors":[],"funders":[{"funder_name":"National Institutes of Health","grant_id":"HL36024","title":null},{"funder_name":"National Institutes of Health","grant_id":"HL122730","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL036024","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01HL122730-03","title":"Mitochondrial dynamics in acute lung injury"},{"funder_name":"National Institutes of Health","grant_id":"5R37HL036024-16","title":"MICROPUNCTURE STUDIES OF LUNG WATER SOLUTE EXCHANGE"}],"total_grants":5,"fwci":0.3193,"citation_percentile":0.60268653,"influential_citations":0,"citation_trend":[{"year":2021,"count":2},{"year":2022,"count":3},{"year":2023,"count":2},{"year":2024,"count":10},{"year":2025,"count":3},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1177/2045894018783735","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1177/2045894018783735","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1177/2045894018783735","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1177/2045894018783735","host_type":"publisher"},{"url":"https://doi.org/10.1177/2045894018783735","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29869931","host_type":"repository"},{"url":"https://doaj.org/article/0975cac258884b47a132ddaf9d05c57e","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6024290","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6024290","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6024290","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6024290?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1177/2045894018783735","host_type":""},{"url":"https://dx.doi.org/10.1177/2045894018783735","host_type":""}],"fields_of_study":["Neonatal Respiratory Health Research","Respiratory Support and Mechanisms","Inhalation and Respiratory Drug Delivery","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":[],"keywords":["Crosstalk","Cell biology","Lung","Signal transduction","Immune system","Medicine","Endothelium","Immunology","Biology","Internal medicine","Capillaries","ARDS","Acute Lung Injury","Alveolar","Lung Repair And Regeneration","Acute Respiratory Distress Syndromes","Diseases of the respiratory system","RC705-779","RC666-701","Diseases of the circulatory (Cardiovascular) system","Review Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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