{"doi":"10.1177/19345798251351004","title":"Effects of protein intake on IGF1 and ROP","abstract":"Background Insulin-like growth factor 1 has been implicated in neural and retinal cell maturation. Optimizing insulin-like growth factor 1 may prevent morbidities, like retinopathy of prematurity. Our objective was to determine the effects of higher protein in parenteral nutrition for very low birth weight infants on insulin-like growth factor 1 and retinopathy of prematurity. Methods This was a post-hoc analysis of a prospective, double blind, randomized control trial of appropriate for gestational age, preterm infants (<1250 grams) randomized to high protein ( N = 53) or conventional protein ( N = 47) in early parenteral nutrition. Goal protein intake was 4 g/kg/d for high protein group and 3 g/kg/d for conventional protein group. Weekly insulin-like growth factor 1 and standard retinal examinations were evaluated. Results Insulin-like growth factor 1 was significantly associated with protein intake group controlling for postnatal age, gestational age and sex. Insulin-like growth factor 1 increased by 21.9% ( p = 0.03) in the high protein group. Any retinopathy of prematurity or severe retinopathy of prematurity (grade ≥3 and/or plus disease) was not associated with group, actual daily protein intake or insulin-like growth factor 1. However, high protein group was associated with lower risk of plus disease (OR 0.17, p = 0.02). Infants with plus disease had 25% lower mean insulin-like growth factor 1 ( p = 0.052). Conclusion Higher protein in parenteral nutrition was associated with increased insulin-like growth factor 1 and lower risk of plus disease in very low birth weight infants.","journal":"Journal of Neonatal-Perinatal Medicine","year":2025,"id":544961,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9585,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1435850,"name":"Angela Holuba","orcid":null,"position":1,"is_corresponding":false},{"id":1435851,"name":"David A. Bateman","orcid":null,"position":2,"is_corresponding":false},{"id":1435852,"name":"Sudha Kashyap","orcid":null,"position":3,"is_corresponding":false},{"id":1271660,"name":"Divya Keerthy","orcid":null,"position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40549958","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}