{"doi":"10.1177/17562848251334517","title":"Factors associated with failure of fecal microbiota transplant for recurrent <i>Clostridioides difficile</i> infection","abstract":"Background: infection (CDI) has emerged as a prevalent and recurrent antibiotic-associated infection. Fecal microbiota transplantation (FMT) is the most effective treatment for recurrent CDI (rCDI). Despite high success rates, FMT is ineffective in 5%-20% of cases. Factors associated with failure have not been clearly defined. Objectives: In this study, we seek to identify factors predictive of FMT failure. Design: Retrospective cohort study. Methods: Clinic at the University of Virginia Health System and received FMT for rCDI between 2013 and 2022. The primary outcome was failure of FMT, defined as either rCDI or all-cause death within 1 year. Results: In total, 240 patients underwent FMT: 70.4% were female, the median age was 68, and the median episode of CDI was 4. A total of 24.6% experienced failure within 1 year (18.3% had rCDI and 7.1% died). Age 70 or older (odds ratio (OR) = 2.66 (1.29-5.67)), ⩾4 episodes of CDI (OR = 3.13 (1.47-7.09)), and diabetes mellitus (OR = 2.82 (1.25-6.50)) were associated with failure on multivariate analysis. Conclusion: Our study shows that FMT remains an effective treatment for rCDI. We highlight several factors associated with FMT failure, such as older age, ⩾4 episodes of CDI, and diabetes mellitus, and the need for additional research to clearly define causality.","journal":"Therapeutic Advances in Gastroenterology","year":2025,"id":552497,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9642,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1260644,"name":"Kibret Yohannes","orcid":null,"position":1,"is_corresponding":false},{"id":276229,"name":"Initha Setiady","orcid":null,"position":2,"is_corresponding":false},{"id":1448560,"name":"Emma Claire Phillips","orcid":"0000-0003-3630-5845","position":3,"is_corresponding":false},{"id":915342,"name":"R. Ann Hays","orcid":"0000-0001-6821-4767","position":4,"is_corresponding":false},{"id":412059,"name":"Brian W. Behm","orcid":"0000-0003-0142-385X","position":5,"is_corresponding":false},{"id":503267,"name":"Cirle A. Warren","orcid":"0000-0002-4417-0445","position":6,"is_corresponding":false},{"id":915343,"name":"Jae Hyun Shin","orcid":"0000-0002-9970-9233","position":7,"is_corresponding":false},{"id":493572,"name":"Joseph Nguyen","orcid":"0009-0008-1585-7230","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:54:33.203144Z","pmid":"40297203","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}