{"doi":"10.1177/15459683241233577","title":"The Utilization of Forced-Rate Cycling to Facilitate Motor Recovery Following Stroke: A Randomized Clinical Trial","abstract":"Background The potential for aerobic exercise (AE) to enhance neuroplasticity post-stroke has been theorized but not systematically investigated. Our aim was to determine the effects of forced-rate AE (FE) paired with upper extremity (UE) repetitive task practice (FE + RTP) compared to time-matched UE RTP (RTP only) on motor recovery. Methods A single center randomized clinical trial was conducted from April 2019 to December 2022. Sixty individuals ≥6 months post-stroke with UE hemiparesis were randomized to FE + RTP (N = 30) or RTP only (N = 30), completing 90-minute sessions, 3×/week for 8 weeks. The FE + RTP group underwent 45-minute of FE (5-minute warm-up, 35-minute main set, and 5-minute cool down) followed by 45-minute of UE RTP. The RTP only group completed 90-minute of RTP. Primary outcomes were the Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT). The 6-minute Walk Test (6MWT, secondary outcome) assessed walking capacity. Results Sixty individuals enrolled and 56 completed the study. The RTP only group completed more RTP in terms of repetitions (411.8 ± 44.4 vs 222.8 ± 28.4, P < .001) and time (72.7 ± 6.7 vs 37.8 ± 2.4 minutes, P < .001) versus FE + RTP. There was no significant difference between groups on the FMA (FE + RTP, 36.2 ± 10.1-44.0 ± 11.8 and RTP only, 34.4 ± 11.0-41.2 ± 13.4, P = .43) or ARAT (FE + RTP, 32.5 ± 16.6-37.7 ± 17.9 and RTP only, 32.8 ± 18.6-36.4 ± 18.5, P = .88). The FE + RTP group demonstrated greater improvements on the 6MWT (274.9 ± 122.0-327.1 ± 141.2 m) versus RTP only (285.5 ± 160.3-316.9 ± 170.0, P = .003). Conclusions There was no significant difference between groups in the primary outcomes. The FE + RTP improved more on the 6MWT, a secondary outcome. Trial Registration: ClinicalTrials.gov : NCT03819764.","journal":"Neurorehabilitation and neural repair","year":2024,"id":454165,"datarank":0.3884565065346912,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.07654027528271576,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.07654027528271576,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":5,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03819764"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1276273,"name":"Andrea Bischof-Bockbrader","orcid":null,"position":1,"is_corresponding":false},{"id":1018066,"name":"Sara Davidson","orcid":"0000-0002-6019-3639","position":2,"is_corresponding":false},{"id":990998,"name":"Yadi Li","orcid":"0000-0003-4930-2168","position":3,"is_corresponding":false},{"id":816298,"name":"Brittany Lapin","orcid":"0000-0002-4314-2282","position":4,"is_corresponding":false},{"id":779146,"name":"Tamanna Singh","orcid":"0000-0002-9591-7860","position":5,"is_corresponding":false},{"id":307564,"name":"John Lee","orcid":"0000-0001-7698-3830","position":6,"is_corresponding":false},{"id":1018067,"name":"François Béthoux","orcid":"0000-0003-4784-9418","position":7,"is_corresponding":false},{"id":415584,"name":"Jay L. Alberts","orcid":"0000-0002-9379-3630","position":8,"is_corresponding":false},{"id":920603,"name":"Susan M. Linder","orcid":"0000-0002-9094-9740","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T02:03:07.923686Z","pmid":"38420848","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}