{"doi":"10.1177/1545109708328931","title":"Body-Fat Abnormalities in Patients With HIV: Progress and Challenges","abstract":"<jats:p>The introduction of newer antiretroviral drugs has provided greater levels of HIV suppression with fewer of the metabolic effects, lipoatrophy, and body habitus changes associated with earlier therapies. Previously classified under the collective term, lipodystrophy, lipoatrophy and body-fat changes are now known to occur independently in some HIV-infected patients, depending on the type and duration of antiretroviral therapy and a myriad of factors including HIV infection alone that contribute significantly to these changes. This article reviews the current scientific literature and recent clinical trial results that distinguish lipoatrophy or dyslipidemia pathophysiologically from body-fat changes seen as central and peripheral lipohypertrophy and fat redistribution, as well as the nature and extent of changes associated with HIV infection alone and newer antiretroviral therapies. This information may assist physicians in identifying individual risk factors and choosing the type of antiretroviral therapy that may minimize these changes without loss of virologic suppression.</jats:p>","journal":"Journal of the International Association of Physicians in AIDS Care","year":2008,"id":29995,"datarank":1.5335186973091042,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":1.0184206166363323,"self_endowment_contribution":0.515098080672772,"citer_contribution":1.0184206166363323,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":30,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164021,"name":"Roger J. Bedimo","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19056708","pmcid":null,"openalex_id":"https://openalex.org/W1975606774","authors":[],"funders":[],"total_grants":0,"fwci":2.4728,"citation_percentile":0.89056815,"influential_citations":1,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":1},{"year":2014,"count":5},{"year":2015,"count":2},{"year":2017,"count":3},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/1545109708328931","host_type":"publisher"},{"url":"https://doi.org/10.1177/1545109708328931","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19056708","host_type":"repository"}],"fields_of_study":["HIV-related health complications and treatments","HIV Research and Treatment","HIV/AIDS drug development and treatment","Medicine","Adipose Tissue","Anti-HIV Agents","HIV Infections","HIV Protease Inhibitors","HIV-1","HIV-Associated Lipodystrophy Syndrome","Humans","Randomized Controlled Trials as Topic","Reverse Transcriptase Inhibitors"],"mesh_terms":["Adipose Tissue","Humans","HIV-1","HIV Infections","Randomized Controlled Trials as Topic","HIV Protease Inhibitors","Reverse Transcriptase Inhibitors","Anti-HIV Agents","HIV-Associated Lipodystrophy Syndrome"],"keywords":["Lipodystrophy","Lipoatrophy","Medicine","Dyslipidemia","Antiretroviral therapy","Human immunodeficiency virus (HIV)","Internal medicine","Immunology","Viral load","Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T01:34:46.054085Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}