{"doi":"10.1177/13872877241300149","title":"Articulatory precision from connected speech as a marker of cognitive decline in Alzheimer’s disease risk-enriched cohorts","abstract":"Background Mild cognitive impairment (MCI) has been recognized as a possible precursor to Alzheimer’s disease (AD). Recent research focusing on connected speech has uncovered various features strongly correlated with MCI due to AD and related dementias. Despite these advancements, the impact of early cognitive decline on articulatory precision has not been thoroughly investigated. Objective This study introduced the phoneme log-likelihood ratio (PLLR) to assess the articulatory precision of speakers across different cognitive status levels and compared its effectiveness to existing well-studied acoustic features. Methods The study utilized speech recordings from a picture description task, which included data from 324 cognitively unimpaired participants with low amyloid-β burden (CU, Aβ( <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mo>−</mml:mo> </mml:math> )), 47 cognitively unimpaired participants with high amyloid-β burden (CU, Aβ( <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mo>+</mml:mo> </mml:math> )), 69 participants with MCI, and 20 participants with dementia. Nine acoustic features were extracted from the speech recordings, covering three categories: speech fluency, speech pace, and articulatory precision. Welch’s <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mi>t</mml:mi> </mml:math> -test and Hedge’s <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" display=\"inline\" overflow=\"scroll\"> <mml:mi>g</mml:mi> </mml:math> were adopted to assess their discriminative ability. Results A reduction in speech fluency and pace was observed among participants in the MCI and dementia groups. The PLLR shows large effect sizes in distinguishing between cognitively unimpaired participants with low Aβ burden and those diagnosed with MCI or dementia. Additionally, the test-retest reliability experiment indicated moderate repeatability of the features under study. Conclusions The study reveals PLLR as a sensitive indicator capable of detecting subtle articulatory variations across groups, while also providing further support for the association between reduced articulatory precision and early cognitive decline.","journal":"Journal of Alzheimer s Disease","year":2024,"id":448022,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9661,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226061,"name":"Kewei Chen","orcid":"0000-0001-8497-3069","position":1,"is_corresponding":false},{"id":311269,"name":"Kimberly D. Mueller","orcid":"0000-0001-8691-9517","position":2,"is_corresponding":false},{"id":297660,"name":"Julie Liss","orcid":"0000-0001-8782-2901","position":3,"is_corresponding":false},{"id":297661,"name":"Visar Berisha","orcid":"0000-0001-8804-8874","position":4,"is_corresponding":false},{"id":1069899,"name":"Lingfeng Xu","orcid":"0000-0002-6554-9438","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:02:08.018689Z","pmid":"39639569","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}