{"doi":"10.1177/1358863x20901599","title":"Association of six-minute walk distance with subsequent lower extremity events in peripheral artery disease","abstract":"The prognostic significance of the six-minute walk distance for lower extremity events in people with peripheral artery disease (PAD) is unknown. This longitudinal study assessed whether a poorer six-minute walk distance at baseline was associated with higher rates of subsequent lower extremity atherosclerotic disease events in PAD. A total of 369 patients (mean age 69.4 ± 10.0 years; mean ankle–brachial index (ABI) 0.67 ± 0.17; 31% women; 30% black individuals) from Chicago-area medical centers with PAD were enrolled. Participants underwent baseline six-minute walk testing and returned for annual study visits. Lower extremity events consisted of one or more of the following: ABI decline greater than 15% or medical record adjudicated lower extremity revascularization, critical limb ischemia, or amputation. At a mean follow-up of 33.3 months, lower extremity events occurred in 66/123 (53.7%) people in the first (worst) tertile of six-minute walk performance, 55/124 (44.4%) in the second tertile, and 56/122 (45.9%) in the third (best) tertile. After adjusting for age, sex, race, ABI, comorbidities, and other confounders, participants in the first (worst) tertile of six-minute walk distance at baseline had higher rates of lower extremity events during follow-up, compared to those in the best tertile at baseline (HR = 1.74, 95% CI 1.17–2.60, p = 0.0067). Among people with PAD, a poorer six-minute walk distance was associated with higher rates of subsequent lower extremity PAD-related events after adjusting for confounders. Further study is needed to determine whether interventions that improve six-minute walk distance can reduce lower extremity adverse events in people with PAD.","journal":"Vascular Medicine","year":2020,"id":86472,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8728,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":45775,"name":"Jack M. Guralnik","orcid":"0000-0001-5108-7263","position":1,"is_corresponding":false},{"id":441255,"name":"Tamar S. Polonsky","orcid":"0000-0003-2112-9244","position":2,"is_corresponding":false},{"id":384825,"name":"Melina R. Kibbe","orcid":"0000-0002-9049-4205","position":3,"is_corresponding":false},{"id":51246,"name":"Lü Tian","orcid":"0000-0002-5893-0169","position":4,"is_corresponding":false},{"id":441256,"name":"Lihui Zhao","orcid":"0000-0002-6877-9490","position":5,"is_corresponding":false},{"id":110087,"name":"Michael H. Criqui","orcid":"0000-0003-0425-9661","position":6,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":7,"is_corresponding":false},{"id":432301,"name":"Lingyu Li","orcid":"0000-0003-4706-6237","position":8,"is_corresponding":false},{"id":441257,"name":"Dongxue Zhang","orcid":"0000-0003-2912-2020","position":9,"is_corresponding":false},{"id":42890,"name":"Mary Mcdermott","orcid":"0000-0002-3724-7619","position":10,"is_corresponding":false},{"id":442496,"name":"Pooja Nayak","orcid":null,"position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:59:03.706190Z","pmid":"32338582","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}