{"doi":"10.1177/10781552211024727","title":"Arsenic trioxide dose capping to decrease toxicity in the treatment of acute promyelocytic leukemia","abstract":"Arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) combination therapy yields high complete remission and disease-free survival rates in acute promyelocytic leukemia (APL). ATO is dosed on actual body weight and high ATO doses in overweight patients may contribute to increased toxicity. We performed a retrospective, two-center study comparing toxicities in patients who received the Lo-Coco et al ATRA/ATO regimen with capped ATO, ≤10 mg/dose, and non-capped ATO, >10 mg/dose. A total of 44 patients were included; 15 received doses ≤10 mg and 29 received >10 mg. During induction, there was no difference in the incidence of grade ≥3 hepatotoxicity, grade ≥3 QTc prolongation, neurotoxicity, and cardiac toxicity between groups. In consolidation, patients receiving >10 mg/dose experienced a greater incidence of neurotoxicity (66.7% vs 22.2%; p = 0.046). Capping doses saved $24634.37/patient and reduced waste of partially-used vials. At a median follow-up of 27 months, no disease relapses occurred in either group. This represents an opportunity to improve the safety profile of this highly effective regimen.","journal":"Journal of Oncology Pharmacy Practice","year":2021,"id":197572,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":771610,"name":"Bryan C. Hambley","orcid":"0000-0001-9105-698X","position":1,"is_corresponding":false},{"id":771611,"name":"Erin Hickey","orcid":"0000-0002-4264-247X","position":2,"is_corresponding":false},{"id":771612,"name":"Sarah Kashanian","orcid":"0000-0003-3537-9076","position":3,"is_corresponding":false},{"id":771613,"name":"Andrew Li","orcid":"0000-0002-7777-9986","position":4,"is_corresponding":false},{"id":474925,"name":"Maria R. Baer","orcid":"0000-0002-9499-1348","position":5,"is_corresponding":false},{"id":771614,"name":"Vu H. Duong","orcid":"0000-0003-0278-7727","position":6,"is_corresponding":false},{"id":771615,"name":"Matthew Newman","orcid":"0000-0002-1402-5554","position":7,"is_corresponding":false},{"id":259085,"name":"Amy E. DeZern","orcid":"0000-0001-5225-4609","position":8,"is_corresponding":false},{"id":232353,"name":"Ivana Gojo","orcid":"0000-0003-0312-3412","position":9,"is_corresponding":false},{"id":304666,"name":"B. Douglas Smith","orcid":"0000-0002-0903-7390","position":10,"is_corresponding":false},{"id":320777,"name":"Mark J. Levis","orcid":"0000-0003-0473-6982","position":11,"is_corresponding":false},{"id":89362,"name":"Ravi Varadhan","orcid":"0000-0002-8434-1034","position":12,"is_corresponding":false},{"id":328149,"name":"Eric A. Gehrie","orcid":"0000-0002-5354-3899","position":13,"is_corresponding":false},{"id":233356,"name":"Ashkan Emadi","orcid":"0000-0003-3769-3210","position":14,"is_corresponding":false},{"id":267503,"name":"Gabriel Ghiaur","orcid":"0000-0002-3955-7944","position":15,"is_corresponding":false},{"id":771609,"name":"Kyle Zacholski","orcid":"0000-0002-0382-0122","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-18T23:50:23.532351Z","pmid":"34134554","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}