{"doi":"10.1177/10732748251397676","title":"Longitudinal Associations of Sedentary Behavior and Physical Activity With Sleep Duration and Quality in Individuals Living With and Beyond Colorectal Cancer","abstract":"IntroductionPoor sleep quality and disturbances are common in colorectal cancer (CRC) survivors. However, the impact of sedentary behavior, standing, and physical activity on sleep duration and quality remains under-explored in this population. Therefore, this study examined longitudinal associations of sedentary behavior, standing, and physical activity with sleep outcomes up to 5 years post-treatment.MethodsA prospective cohort study was conducted among 401 survivors of stage I-III CRC, with repeated measures up to 60 months post-treatment. Thigh-worn accelerometers were used to measure sedentary time (per 2h/day), standing (per 1h/day), and various levels of physical activity (per 1h/day). Sleep duration (h/night) and variability (0%-100%; higher variability equals more sleep disruption) were determined from self-reported sleep times. Sleep quality and insomnia symptoms were assessed using the PSQI and EORTC questionnaires, respectively, where higher scores indicated worsened symptoms. Longitudinal associations were analyzed using confounder-adjusted linear mixed models.ResultsTotal mean sedentary time was 10.3 ± 1.8 h/day, mean standing time was 2.9 ± 1.2 h/day, mean total physical activity was 1.5 ± 0.6 h/day, and mean sleep duration was 8.7 ± 1.0 h/night at 6 weeks post-treatment. More sedentary behavior was longitudinally associated with a shorter sleep duration (β = -0.28; 95%CI = -0.35, -0.21). More standing was associated with a shorter sleep duration (β = -0.21; 95%CI = -0.25, -0.16), higher sleep variability (β = 0.29%; 95%CI = 0.03, 0.55), improved sleep quality (β = -0.24; 95%CI = -0.43, -0.04), and reduced insomnia symptoms (β = -2.00; 95%CI = -3.27, -0.72). More total physical activity was associated with a shorter sleep duration (β = -0.31; 95%CI = -0.41, -0.21) and higher sleep variability (β = 0.59%; 95%CI = 0.11, 1.10). More moderate-to-vigorous physical activity was associated with a shorter sleep duration (β = -0.04; 95%CI = -0.07, -0.00) and reduced insomnia symptoms (β = -1.74; 95%CI = -2.69, -0.79).ConclusionOur findings suggest that physical (in)activity and standing are relevant for sleep-related symptoms in CRC survivors. Future studies should examine whether substituting sedentary behavior with standing and/or physical activity may alleviate sleep-related symptoms in CRC survivors.","journal":"Cancer Control","year":2025,"id":548511,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1441691,"name":"Laurien M. Buffart","orcid":"0000-0002-8095-436X","position":1,"is_corresponding":false},{"id":400522,"name":"Martijn J.L. Bours","orcid":"0000-0002-5558-1258","position":2,"is_corresponding":false},{"id":400523,"name":"Stéphanie O. Breukink","orcid":"0000-0002-5445-4011","position":3,"is_corresponding":false},{"id":1442214,"name":"Maryska Janssen-Heijnen","orcid":null,"position":4,"is_corresponding":false},{"id":1442215,"name":"Joop Konsten","orcid":null,"position":5,"is_corresponding":false},{"id":400526,"name":"Eric T.P. Keulen","orcid":"0000-0001-6666-8773","position":6,"is_corresponding":false},{"id":1441692,"name":"Annemone Siffels","orcid":"0009-0009-0008-5781","position":7,"is_corresponding":false},{"id":6534,"name":"Annemarie Koster","orcid":"0000-0003-1583-7391","position":8,"is_corresponding":false},{"id":1441693,"name":"Kenneth Meijer","orcid":"0000-0001-8236-8754","position":9,"is_corresponding":false},{"id":249994,"name":"Frank A. J. L. Scheer","orcid":"0000-0002-2014-7582","position":10,"is_corresponding":false},{"id":1110984,"name":"Karen Steindorf","orcid":"0000-0001-5215-5651","position":11,"is_corresponding":false},{"id":1442216,"name":"Judith de Vos Geelen","orcid":null,"position":12,"is_corresponding":false},{"id":392603,"name":"Matty P. Weijenberg","orcid":"0000-0003-1695-4768","position":13,"is_corresponding":false},{"id":400519,"name":"Eline H. van Roekel","orcid":"0000-0002-9402-2029","position":14,"is_corresponding":false},{"id":1441690,"name":"Koen G. Frenken","orcid":"0009-0002-3893-5525","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:53:58.530220Z","pmid":"41234203","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}