{"doi":"10.1177/10668969241300487","title":"Transdifferentiation of Secretory Carcinoma to Metaplastic Carcinoma at Metastatic Site","abstract":"<jats:p>\n                    Secretory carcinoma is a rare breast tumor driven by\n                    <jats:italic toggle=\"yes\">ETV6::NTRK3</jats:italic>\n                    fusion. It has characteristic morphologic features and identification of these tumors is critical as these patients may benefit from TRK inhibitors. Morphologic shift upon treatment has not been reported in secretory carcinoma or other\n                    <jats:italic toggle=\"yes\">NTRK</jats:italic>\n                    -driven tumors. Herein we describe a patient with secretory carcinoma showing transdifferentiation into metaplastic carcinoma (spindle cell and squamous cell carcinoma) at the metastatic site following treatment. Identification of these morphologic shifts is crucial for accurate classification and identification of potential resistant mechanisms.\n                  </jats:p>","journal":"International Journal of Surgical Pathology","year":2025,"id":646271,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1683233,"name":"Arielle Medford","orcid":null,"position":1,"is_corresponding":false},{"id":249906,"name":"Amy Ly","orcid":"0000-0002-3889-1123","position":2,"is_corresponding":false},{"id":417,"name":"Ivan Chebib","orcid":"0000-0002-6826-0226","position":3,"is_corresponding":false},{"id":958771,"name":"Bariş Boyraz","orcid":"0000-0002-1270-553X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Transdifferentiation of Secretory Carcinoma to Metaplastic Carcinoma at Metastatic Site","abstract":"<jats:p>\n                    Secretory carcinoma is a rare breast tumor driven by\n                    <jats:italic toggle=\"yes\">ETV6::NTRK3</jats:italic>\n                    fusion. It has characteristic morphologic features and identification of these tumors is critical as these patients may benefit from TRK inhibitors. Morphologic shift upon treatment has not been reported in secretory carcinoma or other\n                    <jats:italic toggle=\"yes\">NTRK</jats:italic>\n                    -driven tumors. Herein we describe a patient with secretory carcinoma showing transdifferentiation into metaplastic carcinoma (spindle cell and squamous cell carcinoma) at the metastatic site following treatment. Identification of these morphologic shifts is crucial for accurate classification and identification of potential resistant mechanisms.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39665211","pmcid":null,"openalex_id":"https://openalex.org/W4405331349","authors":[],"funders":[],"total_grants":0,"fwci":0.2883,"citation_percentile":0.62840878,"influential_citations":0,"citation_trend":[{"year":2026,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/10668969241300487","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1177/10668969241300487","host_type":"publisher"},{"url":"https://doi.org/10.1177/10668969241300487","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39665211","host_type":"repository"}],"fields_of_study":["Neuroendocrine Tumor Research Advances","Microtubule and mitosis dynamics","Lung Cancer Research Studies","Humans","Female","Cell Transdifferentiation","Breast Neoplasms","Carcinoma","Middle Aged","Carcinoma, Squamous Cell","Oncogene Proteins, Fusion","ETS Translocation Variant 6 Protein","Receptor, trkC","Secretory breast carcinoma"],"mesh_terms":["ETS Translocation Variant 6 Protein","Breast Neoplasms","Carcinoma","Carcinoma, Squamous Cell","Female","Humans","Middle Aged","Oncogene Proteins, Fusion","Receptor, trkC","Cell Transdifferentiation"],"keywords":["Carcinoma","Pathology","Cancer research","Basal cell","Medicine","Metaplastic carcinoma","Internal medicine","Cancer","Breast cancer","Transdifferentiation","Secretory Carcinoma","Ntrk"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T12:25:38.582041Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}