{"doi":"10.1177/1039856220943033","title":"The impact of ‘cluster maintenance TMS’ on irritability occurring in major depressive disorder","abstract":"<jats:sec>\n                    <jats:title>Objective:</jats:title>\n                    <jats:p>To determine the impact of clustered maintenance transcranial magnetic stimulation (TMS) on irritability occurring in treatment-resistant major depressive disorder (MDD).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:</jats:title>\n                    <jats:p>A naturalistic study of 106 courses that includes pre- and posttreatment assessments of subjective and objective depression and a subjective measure of irritability developed for this study.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>\n                      Forty-six participants (35 females), mean age 43.2 years (14.3), completed 106 courses. There was a significant reduction in irritability and depression scores (\n                      <jats:italic toggle=\"yes\">p</jats:italic>\n                      &lt; .001). The change in irritability scores was significantly correlated with the change in depression scores,\n                      <jats:italic toggle=\"yes\">r</jats:italic>\n                      = .40,\n                      <jats:italic toggle=\"yes\">p</jats:italic>\n                      &lt; .001.\n                    </jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:</jats:title>\n                    <jats:p>TMS has the capacity to reduce the irritability co-occurring with treatment-resistant MDD, known to be responsive to TMS. This increases the possibility of using TMS in the treatment of irritability co-occurring with other disorders or standing alone (should irritability be categorized as a stand-alone disorder).</jats:p>\n                  </jats:sec>","journal":"Australasian Psychiatry","year":2021,"id":600006,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1537990,"name":"Yvonne Turnier-Shea","orcid":null,"position":1,"is_corresponding":false},{"id":1537991,"name":"Sheila Erger","orcid":null,"position":2,"is_corresponding":false},{"id":1537992,"name":"Tamara May","orcid":null,"position":3,"is_corresponding":false},{"id":1537989,"name":"Saxby Pridmore","orcid":"0000-0002-9170-1798","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The impact of 'cluster maintenance TMS' on irritability occurring in major depressive disorder.","abstract":"<h4>Objective</h4>To determine the impact of clustered maintenance transcranial magnetic stimulation (TMS) on irritability occurring in treatment-resistant major depressive disorder (MDD).<h4>Method</h4>A naturalistic study of 106 courses that includes pre- and posttreatment assessments of subjective and objective depression and a subjective measure of irritability developed for this study.<h4>Results</h4>Forty-six participants (35 females), mean age 43.2 years (14.3), completed 106 courses. There was a significant reduction in irritability and depression scores (<i>p</i> < .001). The change in irritability scores was significantly correlated with the change in depression scores, <i>r</i> = .40, <i>p</i> < .001.<h4>Conclusion</h4>TMS has the capacity to reduce the irritability co-occurring with treatment-resistant MDD, known to be responsive to TMS. This increases the possibility of using TMS in the treatment of irritability co-occurring with other disorders or standing alone (should irritability be categorized as a stand-alone disorder).","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32722962","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[],"fields_of_study":[],"mesh_terms":["Humans","Treatment Outcome","Adult","Female","Transcranial Magnetic Stimulation","Depressive Disorder, Treatment-Resistant","Major Depressive Disorder"],"keywords":["Transcranial magnetic stimulation","Major Depressive Disorder","Irritability"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T11:58:17.233365Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}