{"doi":"10.1177/1010428317706430","title":"MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact","abstract":"<jats:p>MicroRNAs are well-known strong RNA regulators modulating whole functional units in complex signaling networks. Regarding clinical application, they have potential as biomarkers for prognosis, diagnosis, and therapy. In this review, we focus on two microRNAs centrally involved in lung cancer progression. MicroRNA-21 promotes and microRNA-34 inhibits cancer progression. We elucidate here involved pathways and imbed these antagonistic microRNAs in a network of interactions, stressing their cancer microRNA biology, followed by experimental and bioinformatics analysis of such microRNAs and their targets. This background is then illuminated from a clinical perspective on microRNA-21 and microRNA-34 as general examples for the complex microRNA biology in lung cancer and its diagnostic value. Moreover, we discuss the immense potential that microRNAs such as microRNA-21 and microRNA-34 imply by their broad regulatory effects. These should be explored for novel therapeutic strategies in the clinic.</jats:p>","journal":"Tumor Biology","year":2017,"id":17756,"datarank":1.2038145519469148,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.7334904195575422,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.7334904195575422,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":21,"citers_with_citation_signal":18,"citers_with_endowment":18,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":125895,"name":"Claudia Göttlich","orcid":null,"position":1,"is_corresponding":false},{"id":125896,"name":"Thorsten Walles","orcid":null,"position":2,"is_corresponding":false},{"id":125897,"name":"Sarah Nietzer","orcid":null,"position":3,"is_corresponding":false},{"id":125898,"name":"Gudrun Dandekar","orcid":null,"position":4,"is_corresponding":false},{"id":125899,"name":"Thomas Dandekar","orcid":null,"position":5,"is_corresponding":false},{"id":125894,"name":"Meik Kunz","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28705115","pmcid":null,"openalex_id":"https://openalex.org/W2737319532","authors":[],"funders":[],"total_grants":0,"fwci":1.0937,"citation_percentile":0.74266373,"influential_citations":0,"citation_trend":[{"year":2019,"count":3},{"year":2020,"count":9},{"year":2021,"count":3},{"year":2022,"count":3},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/1010428317706430","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/1010428317706430","host_type":"GOLD"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/1010428317706430","host_type":"publisher"},{"url":"http://journals.sagepub.com/doi/pdf/10.1177/1010428317706430","host_type":"publisher"},{"url":"http://journals.sagepub.com/doi/full-xml/10.1177/1010428317706430","host_type":"publisher"},{"url":"https://doi.org/10.1177/1010428317706430","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28705115","host_type":"repository"},{"url":"https://doaj.org/article/c0b682f0595040adb0a80f7a367c421a","host_type":"repository"},{"url":"http://publica.fraunhofer.de/documents/N-477372.html","host_type":"repository"},{"url":"https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/15839","host_type":"repository"},{"url":"https://publica.fraunhofer.de/handle/publica/250951","host_type":"repository"}],"fields_of_study":["MicroRNA in disease regulation","Cancer-related molecular mechanisms research","Circular RNAs in diseases","Biology","Medicine","Biomarkers, Tumor","Computational Biology","Disease Progression","Gene Expression Regulation, Neoplastic","Humans","Lung Neoplasms","MicroRNAs","Prognosis"],"mesh_terms":["Humans","Lung Neoplasms","Prognosis","Biomarkers, Tumor","Gene Expression Regulation, Neoplastic","Disease Progression","Computational Biology","MicroRNAs"],"keywords":["microRNA","In silico","Biology","Lung cancer","Cancer","Bioinformatics","Computational biology","Cancer research","Medicine","Genetics","Oncology","Gene","Biomarker","Therapeutic Strategy","microRNAs","Microrna–target Interaction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T22:17:56.412420Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}