{"doi":"10.1177/070674370200601s08","title":"Is there stimulant sensitivity in children?","abstract":"<jats:p>It has been suggested that exposure to stimulants alters the dopamine system and thus enhances sensitivity to stimulants and possibly other drugs. Sensitization has been induced experimentally in animals, especially in rats, and has been shown to be long-lasting. In addition, cross-sensitization across different compounds has been demonstrated. The animal data have raised concern that exposure to methylphenidate in childhood may enhance the risk for later abuse of stimulants and other drugs.</jats:p>\n                  <jats:p>We review the evidence bearing on sensitization in children treated with stimulants and followed into adulthood. None of four clinic-based studies found an excess of drug abuse in children previously treated with stimulants. A school-based longitudinal study obtained a relationship between early stimulant treatment and later drug use, without controlling for clinical confounds. The single prospective-controlled study of children who received placebo or methylphenidate does not support the sensitization hypothesis.</jats:p>","journal":"Journal of Attention Disorders","year":2002,"id":28986,"datarank":0.5569383133336213,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.28817439294941305,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.28817439294941305,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":5,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":160920,"name":"S. Mannuzza","orcid":null,"position":1,"is_corresponding":false},{"id":160919,"name":"R. Klein","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12685520","pmcid":null,"openalex_id":"https://openalex.org/W2426593116","authors":[],"funders":[],"total_grants":0,"fwci":0.2149,"citation_percentile":0.44779104,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/070674370200601S08","host_type":"publisher"},{"url":"https://doi.org/10.1177/070674370200601s08","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12685520","host_type":"repository"}],"fields_of_study":["Neurotransmitter Receptor Influence on Behavior","Attention Deficit Hyperactivity Disorder","Forensic Toxicology and Drug Analysis","Psychology","Medicine","Adolescent","Adult","Animals","Arousal","Attention Deficit Disorder with Hyperactivity","Central Nervous System Stimulants","Child","Humans","Longitudinal Studies","Methylphenidate","Prospective Studies","Risk Factors","Substance-Related Disorders"],"mesh_terms":["Adolescent","Adult","Central Nervous System Stimulants","Animals","Arousal","Attention Deficit Disorder with Hyperactivity","Child","Humans","Longitudinal Studies","Methylphenidate","Prospective Studies","Risk Factors","Substance-Related Disorders"],"keywords":["Methylphenidate","Stimulant","Sensitization","Psychology","Drugs of abuse","Drug","Substance abuse","Placebo","Psychiatry","Pharmacology","Attention deficit hyperactivity disorder","Medicine","Neuroscience"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T22:28:16.522249Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}