{"doi":"10.1177/0310057x0503300301","title":"Comparative Study between Propofol in a Long-chain Triglyceride and Propofol in a Medium/Long-chain Triglyceride during Sedation with Target-controlled Infusion","abstract":"<jats:p>\n                    This study was performed to compare the pharmacological characteristics of propofol in an emulsion of both medium- and long-chain triglycerides (MCT/LCT) with those of propofol in an LCT emulsion, by measuring the sedative level and the plasma concentration of propofol during sedation using a target-controlled infusion (TCI) technique. Forty ASA 1 or 2 adult patients who required spinal anaesthesia for surgery were enrolled in this study. The patients were divided into two groups: a propofol LCT group (n=20) and a propofol MCT/LCT group (n=20). Propofol was injected intravenously at target blood concentrations of 2.0, 3.0 and 4.0 μg.ml\n                    <jats:sup>–1</jats:sup>\n                    . The bispectral (BIS\n                    <jats:sup>®</jats:sup>\n                    ) index was recorded, and arterial blood was drawn to measure the actual plasma concentrations of propofol at each predicted concentration. Propofol was assayed by high-performance liquid chromatography. Propofol MCT/LCT was associated with significantly less pain than propofol LCT (P&lt;0.05). There were no significant differences between the two groups in BIS® index or in plasma concentration of propofol at each predicted concentration. Computer-generated TCI of propofol MCT/LCT during sedation is comparable with that of propofol LCT with respect to pharmacokinetics and pharmacodynamics. The formulation of MCT/LCT has a beneficial effect with respect to less pain on injection.\n                  </jats:p>","journal":"Anaesthesia and Intensive Care","year":2005,"id":33730,"datarank":0.49018371800988414,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.19829719565158707,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.19829719565158707,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":6,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":175907,"name":"S. Iwasaki","orcid":null,"position":1,"is_corresponding":false},{"id":175908,"name":"S-W. Jeong","orcid":null,"position":2,"is_corresponding":false},{"id":175909,"name":"S-I. Ishiyama","orcid":null,"position":3,"is_corresponding":false},{"id":175910,"name":"A. Namiki","orcid":null,"position":4,"is_corresponding":false},{"id":175906,"name":"M. Yamakage","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15973918","pmcid":null,"openalex_id":"https://openalex.org/W2405416670","authors":[],"funders":[],"total_grants":0,"fwci":0.3135,"citation_percentile":0.6607249,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2025,"count":1}],"oa_status":"bronze","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/0310057X0503300301","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/0310057X0503300301","host_type":"BRONZE"},{"url":"https://journals.sagepub.com/doi/pdf/10.1177/0310057X0503300301","host_type":"publisher"},{"url":"https://doi.org/10.1177/0310057x0503300301","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15973918","host_type":"repository"}],"fields_of_study":["Anesthesia and Sedative Agents","Anesthesia and Neurotoxicity Research","Anesthesia and Pain Management","Medicine","Adult","Anesthetics, Inhalation","Blood Pressure","Chemistry, Pharmaceutical","Procedural Sedation","Double-Blind Method","Emulsions","Female","Heart Rate","Humans","Male","Middle Aged","Propofol","Triglycerides"],"mesh_terms":["Adult","Blood Pressure","Chemistry, Pharmaceutical","Double-Blind Method","Emulsions","Female","Heart Rate","Humans","Male","Middle Aged","Triglycerides","Propofol","Conscious Sedation","Procedural Sedation","Anesthetics, Inhalation"],"keywords":["Propofol","Medicine","Sedation","Anesthesia","Pharmacokinetics","Triglyceride","Bispectral index","Pharmacodynamics","Arterial blood","Sedative","Lipid emulsion","Pharmacology","Surgery","Internal medicine","Cholesterol","Parenteral nutrition"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T16:47:14.668006Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}