{"doi":"10.1177/0269881106074065","title":"Placental transfer of quetiapine in relation to P-glycoprotein activity","abstract":"<jats:p>Atypical antipsychotic drugs are well tolerated and thus often preferred in women of fertile age; yet the information on their placental transfer and use during the prenatal period is limited. The aim of this study was to study the placental transfer of quetiapine, a widely used atypical antipsychotic, with special reference to the role of the placental transporter protein, P-glycoprotein (P-gp). This was performed in 18 dually perfused placentas, using the well established P-gp inhibitors PSC833 (valspodar) and GG918 to inhibit the function of P-gp. We also aimed to clarify the significance of two potentially functional ABCB1 single nuclear polymorphisms (SNPs), 2677G&gt; T/A and 3435C&gt; T, on the transplacental transfer (TPT) of quetiapine. The placental transfer of quetiapine in the control group as measured by TPTAUC % (absolute fraction of the dose crossing placenta) was 3.7%, which is 29% less than the transfer of the freely diffusible antipyrine, which was 5.2%. The P-gp inhibitors had no significant effect on the transfer of quetiapine as measured by TPTAUC % ( P = 0.77). No correlation was found between the transplacental transfer of quetiapine (TPTAUC %) and placental P-gp expression ( P = 0.61). The 3435T allele in exon 26 was associated with significantly higher placental transfer of quetiapine ( P = 0.04). We conclude that quetiapine passes the human placenta but that the blood—placental barrier partially limits the transplacental transfer of quetiapine. Administration of P-gp inhibiting drugs with quetiapine is not likely to increase fetal exposure to quetiapine, although the ABCB1 C3435T polymorphism may contribute to inter-individual variation in fetal exposure to quetiapine.</jats:p>","journal":"Journal of Psychopharmacology","year":2007,"id":26129,"datarank":0.5495342469194471,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.0,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":151879,"name":"Tuija Heikkinen","orcid":null,"position":1,"is_corresponding":false},{"id":151880,"name":"Sebastian Härtter","orcid":null,"position":2,"is_corresponding":false},{"id":151881,"name":"Jukka Hakkola","orcid":null,"position":3,"is_corresponding":false},{"id":151882,"name":"Kristo Hakala","orcid":null,"position":4,"is_corresponding":false},{"id":20005,"name":"Ola Wallerman","orcid":"0000-0003-1037-7904","position":5,"is_corresponding":false},{"id":151883,"name":"Mia Wadelius","orcid":null,"position":6,"is_corresponding":false},{"id":151884,"name":"Claes Wadelius","orcid":null,"position":7,"is_corresponding":false},{"id":151885,"name":"Kari Laine","orcid":null,"position":8,"is_corresponding":false},{"id":151878,"name":"Melissa Rahi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17259208","pmcid":null,"openalex_id":"https://openalex.org/W17259208","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.00226163,"influential_citations":2,"citation_trend":[],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/0269881106074065","host_type":"publisher"},{"url":"http://ci.nii.ac.jp/naid/40019215252","host_type":"journal"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Schizophrenia research and treatment","Medicine","ATP Binding Cassette Transporter, Subfamily B, Member 1","Acridines","Alleles","Antipsychotic Agents","Antipyrine","Cyclosporins","Dibenzothiazepines","Drug Interactions","Exons","Female","Gene Expression","Genotype","Humans","Immunoblotting","In Vitro Techniques","Maternal-Fetal Exchange","Perfusion","Placenta","Polymorphism, Single Nucleotide","Pregnancy","Quetiapine Fumarate","Tetrahydroisoquinolines"],"mesh_terms":["Placenta","Humans","Antipyrine","Tetrahydroisoquinolines","Acridines","Dibenzothiazepines","Cyclosporins","Antipsychotic Agents","Immunoblotting","Perfusion","Gene Expression","Pregnancy","Maternal-Fetal Exchange","Drug Interactions","Genotype","Polymorphism, Single Nucleotide","Alleles","Exons","Female","In Vitro Techniques","Quetiapine Fumarate","ATP Binding Cassette Transporter, Subfamily B, Member 1"],"keywords":["Computer science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Quality Education"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T11:50:18.535106Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}