{"doi":"10.1177/0260106020928667","title":"Assessing the effectiveness of actionable nutrigenomics and lifestyle genomics interventions for weight management in clinical practice: A critical, scoping review with directions for future research","abstract":"<jats:sec>\n                    <jats:title>Background:</jats:title>\n                    <jats:p>The use of nutrigenomics and lifestyle genomics in clinical practice has the potential to optimize weight-related outcomes for patients.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:</jats:title>\n                    <jats:p>A scoping review was conducted to summarize and evaluate the current body of knowledge related to the effectiveness of providing DNA-based lifestyle advice on weight-related outcomes, with the aim of providing direction for future research.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:</jats:title>\n                    <jats:p>Primary studies were included if they were written in English, evaluated weight-related and/or body mass index and/or body composition outcomes, and provided participants with an actionable genetic-based lifestyle intervention; interventions that only provided information on genetic risk for diseases/conditions were excluded. Data was extracted from each article meeting inclusion criteria ( N=3) and the studies were critically appraised for methodological limitations.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>Research in this area is promising, but limited. Specific limitations relate to study designs, the nature of the recommendations provided to participants, small (underpowered) sample sizes, the use of self-reported weight/BMI data and lack of consideration of important confounding factors.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>Therefore, the effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined. Recommendations for future research are detailed in the present manuscript.</jats:p>\n                  </jats:sec>","journal":"Nutrition and Health","year":2020,"id":618033,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":676409,"name":"Jason Gilliland","orcid":"0000-0002-2909-2178","position":1,"is_corresponding":false},{"id":1594080,"name":"Janet Madill","orcid":null,"position":2,"is_corresponding":false},{"id":1594079,"name":"Justine Horne","orcid":"0000-0002-9176-9645","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Assessing the effectiveness of actionable nutrigenomics and lifestyle genomics interventions for weight management in clinical practice: A critical, scoping review with directions for future research","abstract":"<jats:sec>\n                    <jats:title>Background:</jats:title>\n                    <jats:p>The use of nutrigenomics and lifestyle genomics in clinical practice has the potential to optimize weight-related outcomes for patients.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:</jats:title>\n                    <jats:p>A scoping review was conducted to summarize and evaluate the current body of knowledge related to the effectiveness of providing DNA-based lifestyle advice on weight-related outcomes, with the aim of providing direction for future research.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:</jats:title>\n                    <jats:p>Primary studies were included if they were written in English, evaluated weight-related and/or body mass index and/or body composition outcomes, and provided participants with an actionable genetic-based lifestyle intervention; interventions that only provided information on genetic risk for diseases/conditions were excluded. Data was extracted from each article meeting inclusion criteria ( N=3) and the studies were critically appraised for methodological limitations.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:</jats:title>\n                    <jats:p>Research in this area is promising, but limited. Specific limitations relate to study designs, the nature of the recommendations provided to participants, small (underpowered) sample sizes, the use of self-reported weight/BMI data and lack of consideration of important confounding factors.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:</jats:title>\n                    <jats:p>Therefore, the effectiveness of nutrigenomics and lifestyle genomics interventions for weight management in clinical practice cannot yet be conclusively determined. Recommendations for future research are detailed in the present manuscript.</jats:p>\n                  </jats:sec>","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32500817","pmcid":null,"openalex_id":"https://openalex.org/W3033294931","authors":[],"funders":[{"funder_name":"Canadian Institutes of Health Research","grant_id":"395167","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"}],"total_grants":2,"fwci":0.3202,"citation_percentile":0.63516172,"influential_citations":0,"citation_trend":[{"year":2020,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.1177/0260106020928667","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.1177/0260106020928667","host_type":"publisher"},{"url":"https://doi.org/10.1177/0260106020928667","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32500817","host_type":"repository"},{"url":"https://dx.doi.org/10.1177/0260106020928667","host_type":""}],"fields_of_study":["Nutrition, Genetics, and Disease","Epigenetics and DNA Methylation","BRCA gene mutations in cancer","03 medical and health sciences","0302 clinical medicine","Body Mass Index","Body Weight","Genomics","Humans","Life Style","Nutrigenomics"],"mesh_terms":["Body Weight","Humans","Life Style","Body Mass Index","Genomics","Nutrigenomics"],"keywords":["Nutrigenomics","Weight management","Medicine","Psychological intervention","Confounding","Body mass index","Intervention (counseling)","Weight loss","MEDLINE","Genomics","Gerontology","Overweight","Obesity","Nursing","Pathology","Nutrition","Physical Activity","Nutrigenetics","Lifestyle Genomics","Body Weight","Humans","Life Style"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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