{"doi":"10.1177/01650254251413161","title":"Sedentary behavior and mobile phone use in anxiety, social anxiety, and panic disorder: A Mendelian randomization study","abstract":"<jats:p>\n                    This two-sample Mendelian randomization (MR) study investigated causal associations of genetic predisposition to sedentary behaviors (television viewing, computer use, driving) and mobile phone use duration with social anxiety/social phobia, an “anxiety, nerves, or generalized anxiety disorder (GAD)” phenotype, and panic attacks. Genome-wide association study (GWAS) summary data were sourced from the IEU OpenGWAS repository, primarily comprising individuals of European ancestry from the UK Biobank (aged 40–69). Independent genome-wide significant single-nucleotide polymorphisms (SNPs) (\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                     &lt; 5 × 10\n                    <jats:sup>−8</jats:sup>\n                    ) were selected as instrumental variables. Causal estimates were primarily derived using inverse-variance weighted (IVW) regression, supplemented by sensitivity analyses. Results demonstrated that genetically predicted mobile phone use was associated with increased liability to both social anxiety or social phobia (β = .011,\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                     = .045) and panic attacks (β = .021,\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                     = .033). Conversely, computer use showed a protective association with panic attacks (β = −0.028,\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                     = .010), whereas television viewing was also associated with higher panic attack risk (β = .020,\n                    <jats:italic toggle=\"yes\">p</jats:italic>\n                     = .047). These findings indicate modest causal effects of specific digital behaviors on anxiety-related outcomes, though interpretations are constrained by phenotypic and sample limitations.\n                  </jats:p>","journal":"International Journal of Behavioral Development","year":2026,"id":4409,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.1237,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2026-01-13","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":45238,"name":"Kuiliang Liu","orcid":"0000-0001-8163-0394","position":1,"is_corresponding":false},{"id":45239,"name":"Zhikai Qin","orcid":"0009-0005-1319-5147","position":2,"is_corresponding":false},{"id":45240,"name":"Haoran He","orcid":null,"position":3,"is_corresponding":false},{"id":45241,"name":"Wanmeng Bu","orcid":null,"position":4,"is_corresponding":false},{"id":45242,"name":"Renyi Liu","orcid":null,"position":5,"is_corresponding":false},{"id":45243,"name":"Yuting Sun","orcid":null,"position":6,"is_corresponding":false},{"id":45244,"name":"Shuya Chen","orcid":"0000-0003-4114-9066","position":7,"is_corresponding":false},{"id":45237,"name":"Shuo Feng","orcid":"0009-0008-3705-544X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}