{"doi":"10.1177/00034894241282582","title":"Establishing Benchmarks for Airway Replacement: Long-Term Outcomes of Tracheal Autografts in a Large Animal Model","abstract":"OBJECTIVE: Airway replacement is a challenging surgical intervention and remains an unmet clinical need. Due to the risk of airway stenosis, anastomotic separation, poor vascularization, and necrosis, it is necessary to establish the gold-standard outcomes of tracheal replacement. In this study, we use a large animal autograft model to assess long-term outcomes following tracheal replacement. METHODS: Four New Zealand White rabbits underwent tracheal autograft surgery and were observed for 6 months. Clinical and radiographic surveillance were recorded, and grafts were analyzed histologically and radiographically at endpoint. RESULTS: All animals survived to the endpoint with minimal respiratory symptoms and normal growth rates. No complications were observed. Computed tomography scans of the post-surgical airway demonstrated graft patency at all time points. Histological sections showed no sign of stenosis or necrosis with preservation of the native structure of the trachea. CONCLUSION: We established benchmarks for airway replacement. Our findings suggest that a rabbit model of tracheal autograft with direct reimplantation is feasible and does not result in graft stenosis or airway collapse.","journal":"Annals of Otology Rhinology & Laryngology","year":2024,"id":481601,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1291758,"name":"Ada C. Sher","orcid":"0000-0002-1238-2953","position":1,"is_corresponding":false},{"id":1322017,"name":"Carmen Arsuaga‐Zorrilla","orcid":null,"position":2,"is_corresponding":false},{"id":1321605,"name":"Humra Shamim","orcid":"0000-0003-0578-1048","position":3,"is_corresponding":false},{"id":672102,"name":"Sarah C. Nyirjesy","orcid":"0000-0001-7304-7211","position":4,"is_corresponding":false},{"id":671658,"name":"Kimberly M. Shontz","orcid":null,"position":5,"is_corresponding":false},{"id":1103499,"name":"Zakarie Hussein","orcid":null,"position":6,"is_corresponding":false},{"id":1307282,"name":"Sarah Sussman","orcid":"0000-0001-7108-5118","position":7,"is_corresponding":false},{"id":670925,"name":"Amy Manning","orcid":"0009-0002-7385-3103","position":8,"is_corresponding":false},{"id":645952,"name":"Tendy Chiang","orcid":"0000-0003-1448-5873","position":9,"is_corresponding":false},{"id":645950,"name":"Lumei Liu","orcid":"0000-0001-9849-6881","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:07:10.067421Z","pmid":"39329196","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}