{"doi":"10.1176/appi.ajp.20250108","title":"Variability Rather Than Means? Harnessing the Adversary to Advance Precision Psychiatry","abstract":null,"journal":"American Journal of Psychiatry","year":2025,"id":596789,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":235291,"name":"David R. Roalf","orcid":"0000-0002-1728-9782","position":1,"is_corresponding":false},{"id":230041,"name":"Daniel H. Wolf","orcid":"0000-0002-9731-8781","position":2,"is_corresponding":false},{"id":230043,"name":"Ruben C. Gur","orcid":"0000-0002-9657-1996","position":3,"is_corresponding":false},{"id":230042,"name":"Raquel E. Gur","orcid":"0000-0002-4082-8502","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Variability Rather Than Means? Harnessing the Adversary to Advance Precision Psychiatry","abstract":"For most studies of the pathophysiology of schizophrenia and other neuropsychiatric disorders where mean group differences are examined, the variance in the data is an adversary in the pursuit of significant findings.In this issue, Omlor et al. ( 1) boldly look at that \"dark side of the moon\" and harness it to illuminate novel associations.Across multiple brain parameters, including cortical thickness, cortical surface area, subcortical volume, and fractional anisotropy in the frontotemporal and subcortical network, patients showed greater variability than healthy control subjects.The authors' contribution is further enhanced by deploying a person-based similarity index (PBSI), which opens a pathway to advancing precision psychiatry.PBSI correlated with psychopathology and also revealed regional differences in variability, uncovering a novel finding that patients had more uniform folding patterns, especially in the right caudal anterior cingulate region.The authors suggest that \"uniform folding may indicate a less flexible interplay between genetic and environmental factors during neurodevelopment.\"Their study further demonstrates the power of large sample sizes and paves the way to novel evaluations of existing data that may eventually contribute to the design of targeted interventions.Omlor et al. examined an adult population, excluding those younger than 18 or older than 65.This decision is reasonable when the focus is on individuals who meet diagnostic criteria for schizophrenia spectrum disorders.However, psychosis pathophysiology arises earlier, during childhood and adolescence, and early identification is a current focus of research (2).It would seem important to examine the neurodevelopmental trajectory of this increased variability in brain parameters.At what age does it appear?How does it evolve into adulthood?Studies sufficiently powered across the age range below 18 are needed to answer this question.Notably, neurodevelopmental studies will not be able to rely on categorical diagnostic criteria, as subthreshold symptoms are more prevalent in this age range.Therefore, examining psychosis dimensionally in adolescence and young","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40165562","pmcid":"PMC13088171","openalex_id":"https://openalex.org/W4409035566","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"R01 MH119185","title":null}],"total_grants":1,"fwci":10.2378,"citation_percentile":0.95703515,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13088171/pdf/nihms-2163149.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13088171/pdf/nihms-2163149.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13088171/","host_type":"repository"},{"url":"https://doi.org/10.1176/appi.ajp.20250108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40165562","host_type":"repository"}],"fields_of_study":["Mental Health and Psychiatry","Health Systems, Economic Evaluations, Quality of Life","Mental Health Research Topics"],"mesh_terms":[],"keywords":["Adversary","Psychology","Computer science","Psychiatry","Computer security","Neuroanatomy","Neuroimaging","Schizophrenia Spectrum And Other Psychotic Disorders"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:17:45.889763Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}