{"doi":"10.1176/appi.ajp.160.5.993","title":"Placental Passage of Antidepressant Medications","abstract":null,"journal":"American Journal of Psychiatry","year":2003,"id":682646,"datarank":0.894536901542767,"base_score":5.963579343618446,"endowment":5.963579343618446,"self_citation_contribution":0.894536901542767,"citation_network_contribution":0.0,"self_endowment_contribution":0.894536901542767,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":388,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":268162,"name":"Zachary N. Stowe","orcid":"0000-0001-6320-8042","position":1,"is_corresponding":false},{"id":507623,"name":"Lori L. Altshuler","orcid":null,"position":2,"is_corresponding":false},{"id":1783370,"name":"Sun Hwang","orcid":null,"position":3,"is_corresponding":false},{"id":1052131,"name":"Emily Lee","orcid":"0009-0001-4921-1488","position":4,"is_corresponding":false},{"id":1783371,"name":"Desiree Haynes","orcid":null,"position":5,"is_corresponding":false},{"id":1667733,"name":"Victoria Hendrick","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Placental Passage of Antidepressant Medications","abstract":"OBJECTIVE: This study determined the placental transfer of antidepressants and their metabolites. METHOD: A total of 38 pregnant women taking citalopram, fluoxetine, paroxetine, or sertraline participated. Maternal and umbilical cord blood samples were obtained to determine antidepressant and metabolite concentrations. RESULTS: Antidepressant and metabolite concentrations were detectable in 86.8% of umbilical cord samples. The mean ratios of umbilical cord to maternal serum concentrations ranged from 0.29 to 0.89. The lowest ratios were for sertraline and paroxetine; the highest were for citalopram and fluoxetine. Maternal doses of sertraline and fluoxetine correlated with umbilical cord concentrations of these medications. CONCLUSIONS: Umbilical cord concentrations of antidepressants and their metabolites were almost invariably lower than corresponding maternal concentrations. Maternal doses predicted umbilical concentrations of fluoxetine and sertraline. Mean umbilical cord to maternal serum ratios were significantly lower for sertraline than fluoxetine, suggesting that sertraline may produce less fetal medication exposure than fluoxetine near delivery.","is_dataset_classified":null,"base_score":5.963579343618446,"endowment":5.963579343618446,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12727706","pmcid":null,"openalex_id":"https://openalex.org/W2101143167","authors":[],"funders":[{"funder_name":"NIMH NIH HHS","grant_id":"MH 01451","title":null}],"total_grants":1,"fwci":17.5847,"citation_percentile":0.99490209,"influential_citations":0,"citation_trend":[{"year":2012,"count":18},{"year":2013,"count":16},{"year":2014,"count":20},{"year":2015,"count":21},{"year":2016,"count":22},{"year":2017,"count":19},{"year":2018,"count":18},{"year":2019,"count":22},{"year":2020,"count":20},{"year":2021,"count":17},{"year":2022,"count":11},{"year":2023,"count":15},{"year":2024,"count":10},{"year":2025,"count":14},{"year":2026,"count":6}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://psychiatryonline.org/doi/10.1176/appi.ajp.160.5.993","host_type":"publisher"},{"url":"https://doi.org/10.1176/appi.ajp.160.5.993","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12727706","host_type":"repository"}],"fields_of_study":["Maternal Mental Health During Pregnancy and Postpartum","Prenatal Substance Exposure Effects","Pregnancy and Medication Impact","Adult","Antidepressive Agents","Citalopram","Depressive Disorder","Dose-Response Relationship, Drug","Female","Fetal Blood","Fluoxetine","Humans","Maternal-Fetal Exchange","Paroxetine","Placenta","Pregnancy","Pregnancy Complications","Pregnancy Outcome","Sertraline"],"mesh_terms":["Adult","Antidepressive Agents","Depressive Disorder","Dose-Response Relationship, Drug","Female","Fetal Blood","Fluoxetine","Humans","Maternal-Fetal Exchange","Placenta","Pregnancy","Pregnancy Complications","Pregnancy Outcome","Citalopram","Paroxetine","Sertraline"],"keywords":["Sertraline","Fluoxetine","Paroxetine","Antidepressant","Umbilical cord","Citalopram","Metabolite","Pharmacology","Reuptake inhibitor","Medicine","Internal medicine","Anesthesia","Serotonin","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T20:58:27.266346Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}