{"doi":"10.1172/jci44165","title":"Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models","abstract":null,"journal":"Journal of Clinical Investigation","year":2010,"id":661242,"datarank":0.7357912167657645,"base_score":4.90527477843843,"endowment":4.90527477843843,"self_citation_contribution":0.7357912167657645,"citation_network_contribution":0.0,"self_endowment_contribution":0.7357912167657645,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":134,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":4850,"name":"Ron Chen","orcid":null,"position":1,"is_corresponding":false},{"id":12798,"name":"Leanne C. 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Using a combination of functional genomics and mouse genetics, we identified a role for the transcription factor Wilms tumor 1 (WT1) as a critical regulator of senescence and proliferation downstream of oncogenic KRAS signaling. Deletion or suppression of Wt1 led to senescence of mouse primary cells expressing physiological levels of oncogenic Kras but had no effect on wild-type cells, and Wt1 loss decreased tumor burden in a mouse model of Kras-driven lung cancer. In human lung cancer cell lines dependent on oncogenic KRAS, WT1 loss decreased proliferation and induced senescence. Furthermore, WT1 inactivation defined a gene expression signature that was prognostic of survival only in lung cancer patients exhibiting evidence of oncogenic KRAS activation. These findings reveal an unexpected role for WT1 as a key regulator of the genetic network of oncogenic KRAS and provide important insight into the mechanisms that regulate proliferation or senescence in response to oncogenic signals.","is_dataset_classified":null,"base_score":4.90527477843843,"endowment":4.90527477843843,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20972333","pmcid":"PMC2965578","openalex_id":"https://openalex.org/W1997324813","authors":[],"funders":[{"funder_name":"NCI NIH HHS","grant_id":"1R01CA138256-01","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA138256","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R01 CA129562","title":null},{"funder_name":"NCI NIH HHS","grant_id":"K08 CA098096","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32 CA128583","title":null},{"funder_name":"NCI NIH HHS","grant_id":"R33 CA128625","title":null},{"funder_name":"NCI NIH HHS","grant_id":"T32 CA009302","title":null},{"funder_name":"NCI NIH HHS","grant_id":"I-K08CA98096-01","title":null}],"total_grants":8,"fwci":4.9795,"citation_percentile":0.96180014,"influential_citations":0,"citation_trend":[{"year":2012,"count":17},{"year":2013,"count":10},{"year":2014,"count":11},{"year":2015,"count":10},{"year":2016,"count":13},{"year":2017,"count":11},{"year":2018,"count":7},{"year":2019,"count":6},{"year":2020,"count":10},{"year":2021,"count":7},{"year":2022,"count":4},{"year":2023,"count":8},{"year":2024,"count":4},{"year":2025,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.jci.org/articles/view/44165/files/pdf","host_type":"journal"},{"url":"http://www.jci.org/articles/view/44165/files/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1172/jci44165","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20972333","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2965578","host_type":"repository"}],"fields_of_study":["Renal and related cancers","Epigenetics and DNA Methylation","Carcinogens and Genotoxicity Assessment","Animals","Cell Line, Tumor","Cell Proliferation","Cell Transformation, Neoplastic","Cellular Senescence","Fibroblasts","Gene Expression Profiling","Humans","Lung Neoplasms","Mice","Proto-Oncogene Proteins","Proto-Oncogene Proteins p21(ras)","RNA Interference","Signal Transduction","WT1 Proteins","ras Proteins"],"mesh_terms":["Animals","Cell Transformation, Neoplastic","Fibroblasts","Humans","Lung Neoplasms","Proto-Oncogene Proteins","Signal Transduction","Proto-Oncogene Proteins p21(ras)","Cellular Senescence","ras Proteins","Gene Expression Profiling","WT1 Proteins","RNA Interference","Cell Line, Tumor","Cell Proliferation","Mice"],"keywords":["KRAS","Carcinogenesis","Senescence","Cancer research","Biology","Wilms' tumor","Cancer","Regulator","Transcription factor","Cell growth","Gene","Cell biology","Genetics","Colorectal cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"geo"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T10:39:16.192073Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}