{"doi":"10.1172/jci38084","title":"Role for α3 integrin in EMT and pulmonary fibrosis","abstract":null,"journal":"Journal of Clinical Investigation","year":2008,"id":597863,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":239537,"name":"Zea Borok","orcid":"0000-0001-8673-8177","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Role for α3 integrin in EMT and pulmonary fibrosis","abstract":"Idiopathic pulmonary fibrosis (IPF) is characterized by progressive (myo)fibroblast accumulation and collagen deposition. One possible source of (myo)fibroblasts is epithelial cells that undergo epithelial-mesenchymal transition (EMT), a process frequently mediated by TGF-beta. In this issue of the JCI, Kim et al. report that epithelial cell-specific deletion of alpha3 integrin prevents EMT in mice, thereby protecting against bleomycin-induced fibrosis (see the related article beginning on page 213). The authors propose a novel mechanism linking TGF-beta and beta-catenin signaling in EMT through integrin-dependent association of tyrosine-phosphorylated beta-catenin and pSmad2 and suggest targeted disruption of this interaction as a potential therapeutic approach.","is_dataset_classified":null,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19104143","pmcid":"PMC2613449","openalex_id":"https://openalex.org/W2016415357","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL89445","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL089445","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R37 HL062569","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL038578","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL064365","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL62569","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL38621","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL062569","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL64365","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL38578","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL038621","title":null},{"funder_name":"National Institutes of Health","grant_id":"1R01HL089445-01A1","title":"Alveolar epithelial-mesenchymal transition (EMT) in pulmonary fibrosis"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL064365-10","title":"Absorption mechanisms for peptide/protein drugs via lung"},{"funder_name":"National Institutes of Health","grant_id":"5R37HL038578-09","title":"LUNG EPITHELIAL TRANSPORT PROPERTIES AND ALVEOLAR EDEMA"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL038621-15","title":"ALVEOLAR EPITHELIAL TRANSPORT--REGULATION/GENE EXPRESSIO"}],"total_grants":15,"fwci":1.7145,"citation_percentile":0.84387129,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":4},{"year":2016,"count":4},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":5},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.jci.org/articles/view/38084/files/pdf","host_type":"journal"},{"url":"http://www.jci.org/articles/view/38084/files/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1172/jci38084","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/19104143","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2613449","host_type":"repository"},{"url":"https://dx.doi.org/10.1172/jci38084","host_type":""}],"fields_of_study":["Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","Wnt/β-catenin signaling in development and cancer","Neonatal Respiratory Health Research","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Antibiotics, Antineoplastic","Bleomycin","Cell Differentiation","Epithelial Cells","Extracellular Matrix","Humans","Integrin alpha3","Mesoderm","Mice","Mice, Knockout","Pulmonary Fibrosis","Signal Transduction","Wnt Proteins","beta Catenin"],"mesh_terms":["Animals","Antibiotics, Antineoplastic","Bleomycin","Cell Differentiation","Epithelial Cells","Extracellular Matrix","Humans","Mesoderm","Pulmonary Fibrosis","Signal Transduction","Mice, Knockout","Integrin alpha3","Wnt Proteins","beta Catenin","Mice"],"keywords":["Integrin","Cancer research","Epithelial–mesenchymal transition","Pulmonary fibrosis","Fibrosis","Bleomycin","Fibroblast","Beta-catenin","Phosphorylation","TGF beta signaling pathway","Tyrosine phosphorylation","Biology","Signal transduction","Medicine","Cell biology","Cell","Pathology","Transforming growth factor","Cancer","Cell culture","Wnt signaling pathway","Internal medicine","Metastasis","Mice, Knockout","Antibiotics, Antineoplastic","Integrin alpha3","Cell Differentiation","Epithelial Cells","Extracellular Matrix","Mesoderm","Wnt Proteins","Mice","Animals","Humans","beta Catenin"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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