{"doi":"10.1172/jci21746","title":"Amyloid at the cutting edge: activation of α-secretase prevents amyloidogenesis in an Alzheimer disease mouse model","abstract":null,"journal":"Journal of Clinical Investigation","year":2004,"id":603819,"datarank":0.6716005221717312,"base_score":4.477336814478207,"endowment":4.477336814478207,"self_citation_contribution":0.6716005221717312,"citation_network_contribution":0.0,"self_endowment_contribution":0.6716005221717312,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":87,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":84331,"name":"Christian Haass","orcid":"0000-0002-4869-1627","position":1,"is_corresponding":false},{"id":219606,"name":"Stefan F. Lichtenthaler","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Amyloid at the cutting edge: activation of α-secretase prevents amyloidogenesis in an Alzheimer disease mouse model","abstract":"The amyloid beta-peptide (A beta peptide) is assumed to play a crucial and early role in the pathogenesis of Alzheimer disease. Thus, strategies for a pharmacotherapy aim at reducing A beta peptide generation, which proteolytically derives from the amyloid precursor protein (APP). The main targets so far have been beta- and gamma-secretase, the two proteases that cleave APP at the N- and C-terminus of the A beta peptide and are thus directly responsible for A beta peptide generation. A different strategy, namely the activation of alpha-secretase, has barely been investigated for its therapeutic potential. alpha-Secretase cleaves within the A beta peptide domain and thus precludes A beta peptide generation. Now, new results demonstrate that activation of alpha-secretase indeed reduces A beta peptide generation and toxicity in vivo.","is_dataset_classified":null,"base_score":4.477336814478207,"endowment":4.477336814478207,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15146234","pmcid":"PMC406534","openalex_id":"https://openalex.org/W2020377057","authors":[],"funders":[],"total_grants":0,"fwci":3.9774,"citation_percentile":0.93710631,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":3},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":5},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":7},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"http://www.jci.org/articles/view/21746/files/pdf","host_type":"journal"},{"url":"http://www.jci.org/articles/view/21746/files/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1172/jci21746","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15146234","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Cholinesterase and Neurodegenerative Diseases","Computational Drug Discovery Methods","Alzheimer Disease","Amyloid","Amyloid Precursor Protein Secretases","Amyloidosis","Animals","Aspartic Acid Endopeptidases","Disease Models, Animal","Endopeptidases","Enzyme Activation","Humans","Mice"],"mesh_terms":["Alzheimer Disease","Amyloid","Amyloidosis","Animals","Disease Models, Animal","Enzyme Activation","Humans","Endopeptidases","Aspartic Acid Endopeptidases","Mice","Amyloid Precursor Protein Secretases"],"keywords":["Alpha secretase","Peptide","P3 peptide","Amyloid precursor protein secretase","Amyloid precursor protein","Proteases","Amyloid beta","BETA (programming language)","Amyloid (mycology)","BACE1-AS","Biochemistry of Alzheimer's disease","Chemistry","Biochemistry","Alzheimer's disease","Cell biology","Biology","Medicine","Enzyme","Disease","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T22:48:33.143886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}