{"doi":"10.1172/jci195839","title":"EV-D68 neurological disease: tipping the scales toward immunopathogenesis","abstract":"<jats:p>\n                    Over the last decade, there have been multiple outbreaks of enterovirus D68 (EV-D68) disease and associated cases of acute flaccid myelitis (AFM). The underlying cause of EV-D68–induced AFM is contentious; whether spinal cord motor neurons are damaged by direct viral infection, infiltration of immune cells, or a combination of both is not clear. In this issue of the\n                    <jats:italic>JCI</jats:italic>\n                    , Woods Acevedo and coworkers used a neonatal WT mouse model of EV-D68 infection to attribute paralytic disease to immune cell infiltration into the spinal cord. The results of their work in cytokine-knockout or immune cell–depleted animals effectively argue that immunopathogenesis plays an integral role in EV-D68–induced AFM.\n                  </jats:p>","journal":"Journal of Clinical Investigation","year":2025,"id":650394,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1046016,"name":"Peter W. Krug","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"EV-D68 neurological disease: tipping the scales toward immunopathogenesis","abstract":"<jats:p>\n                    Over the last decade, there have been multiple outbreaks of enterovirus D68 (EV-D68) disease and associated cases of acute flaccid myelitis (AFM). The underlying cause of EV-D68–induced AFM is contentious; whether spinal cord motor neurons are damaged by direct viral infection, infiltration of immune cells, or a combination of both is not clear. In this issue of the\n                    <jats:italic>JCI</jats:italic>\n                    , Woods Acevedo and coworkers used a neonatal WT mouse model of EV-D68 infection to attribute paralytic disease to immune cell infiltration into the spinal cord. The results of their work in cytokine-knockout or immune cell–depleted animals effectively argue that immunopathogenesis plays an integral role in EV-D68–induced AFM.\n                  </jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40759565","pmcid":"PMC12321398","openalex_id":"https://openalex.org/W4412938514","authors":[],"funders":[],"total_grants":0,"fwci":1.5232,"citation_percentile":0.84472229,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.jci.org/articles/view/195839/files/pdf","host_type":"journal"},{"url":"http://www.jci.org/articles/view/195839/files/pdf","host_type":"publisher"},{"url":"https://www.jci.org/articles/view/195839/files/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1172/jci195839","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40759565","host_type":"repository"},{"url":"https://doaj.org/article/52a582f03d63484c9a216f66f361cdee","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12321398","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12321398","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12321398?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Viral Infections and Immunology Research","Whipple's Disease and Interleukins","RNA Research and Splicing","Animals","Humans","Mice","Enterovirus D, Human","Enterovirus Infections","Myelitis","Disease Models, Animal","Neuromuscular Diseases","Spinal Cord","Mice, Knockout","Motor Neurons","Central Nervous System Viral Diseases","acute flaccid myelitis"],"mesh_terms":["Animals","Disease Models, Animal","Enterovirus Infections","Humans","Motor Neurons","Myelitis","Neuromuscular Diseases","Spinal Cord","Mice, Knockout","Central Nervous System Viral Diseases","Enterovirus D, Human","Mice"],"keywords":["Disease","Medicine","Immunology","Psychology","Pathology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T05:24:06.859456Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}