{"doi":"10.1172/jci195764","title":"Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells","abstract":"Epstein-Barr virus (EBV) is of growing interest for its potential role in neurodegenerative diseases such as multiple sclerosis (MS) and its possible utility as a therapeutic target in herpesvirus-associated chronic diseases. The effects of brincidofovir (BCV) on EBV reactivation were evaluated in vitro using EBV-infected spontaneous lymphoblastoid cell lines (SLCLs) and peripheral blood mononuclear cells (PBMCs) derived from patients with MS and healthy controls. In addition, a B lymphoblastoid cell line and PBMCs from common marmosets (Callithrix jacchus) naturally infected with an EBV-related gammaherpesvirus (Callitrichine herpesvirus 3, CalHV-3) were used to measure BCV efficacy in a nonhuman primate model. BCV significantly inhibited gammaherpesvirus reactivation, with decreased lytic and latent viral transcript expression. These results suggest that BCV may be a useful antiviral for inhibiting EBV activity in patients with MS. Additionally, this work further validates the utility of CalHV-3 in marmosets as a translational model for the investigation of successful EBV-targeting therapeutics.","journal":"Journal of Clinical Investigation","year":2025,"id":535529,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9676,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1419602,"name":"Madeleine R. Druker","orcid":null,"position":1,"is_corresponding":false},{"id":654891,"name":"Maria Chiara Monaco","orcid":"0000-0003-0771-0980","position":2,"is_corresponding":false},{"id":497905,"name":"Emily Stack","orcid":"0009-0008-0115-7321","position":3,"is_corresponding":false},{"id":1419603,"name":"Paige Zimmerman","orcid":null,"position":4,"is_corresponding":false},{"id":930483,"name":"Amanda J. Lee","orcid":null,"position":5,"is_corresponding":false},{"id":1419155,"name":"Izabela Bialuk","orcid":"0000-0002-4587-8613","position":6,"is_corresponding":false},{"id":1352339,"name":"William A. Frazier","orcid":null,"position":7,"is_corresponding":false},{"id":230799,"name":"Irene Cortese","orcid":"0000-0001-9631-7181","position":8,"is_corresponding":false},{"id":1419604,"name":"Heather Lyons Narver","orcid":null,"position":9,"is_corresponding":false},{"id":1317886,"name":"Masatoshi Hazama","orcid":null,"position":10,"is_corresponding":false},{"id":1419605,"name":"Fuminao Yoshida","orcid":null,"position":11,"is_corresponding":false},{"id":410862,"name":"Xiaofan Li","orcid":"0000-0003-4168-0068","position":12,"is_corresponding":false},{"id":433935,"name":"Laurie T. Krug","orcid":"0000-0002-9648-522X","position":13,"is_corresponding":false},{"id":391713,"name":"Stacey L. Piotrowski","orcid":null,"position":14,"is_corresponding":false},{"id":247665,"name":"Steven Jacobson","orcid":"0000-0003-3127-1287","position":15,"is_corresponding":false},{"id":1419601,"name":"Abaigeal Donaldson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41289155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}