{"doi":"10.1172/jci190106","title":"B cells shape naive CD8+ T cell programming","abstract":"The presence of B cells is essential for the formation of CD8+ T cell memory after infection and vaccination. In this study, we investigated whether B cells influence the programming of naive CD8+ T cells prior to their involvement in an immune response. RNA sequencing indicated that B cells are necessary for sustaining the FOXO1-controlled transcriptional program, which is critical for homeostasis of these T cells. Without an appropriate B cell repertoire, mouse naive CD8+ T cells exhibit a terminal, effector-skewed phenotype, which significantly impacts their response to vaccination. A similar effector-skewed phenotype with reduced FOXO1 expression was observed in naive CD8+ T cells from human patients undergoing B cell-depleting therapies. Furthermore, we show that patients without B cells have a defect in generating long-lived CD8+ T cell memory following COVID vaccination. In summary, we demonstrate that B cells promote the quiescence of naive CD8+ T cells, poising them to become memory cells upon vaccination.","journal":"Journal of Clinical Investigation","year":2025,"id":550487,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1314014,"name":"Miguel Guerrero Moreno","orcid":"0009-0000-5308-0428","position":1,"is_corresponding":false},{"id":518177,"name":"Jennifer Cimons","orcid":"0000-0002-8111-8697","position":2,"is_corresponding":false},{"id":623478,"name":"Marc D’Antonio","orcid":"0000-0002-4243-7230","position":3,"is_corresponding":false},{"id":11285,"name":"Tonya M. Brunetti","orcid":"0000-0002-2228-2198","position":4,"is_corresponding":false},{"id":1072219,"name":"Michael Harbell","orcid":null,"position":5,"is_corresponding":false},{"id":1013336,"name":"Sean Selva","orcid":null,"position":6,"is_corresponding":false},{"id":1013328,"name":"Christopher Mizenko","orcid":null,"position":7,"is_corresponding":false},{"id":1013122,"name":"Tyler L. Borko","orcid":"0000-0002-6679-1867","position":8,"is_corresponding":false},{"id":552727,"name":"Erika Lasda","orcid":"0000-0001-5698-8386","position":9,"is_corresponding":false},{"id":87044,"name":"Jay R. Hesselberth","orcid":"0000-0002-6299-179X","position":10,"is_corresponding":false},{"id":231988,"name":"Elena W.Y. Hsieh","orcid":"0000-0003-3969-6597","position":11,"is_corresponding":false},{"id":428918,"name":"Michael R. Verneris","orcid":"0000-0002-7097-5917","position":12,"is_corresponding":false},{"id":854713,"name":"Amanda L. Piquet","orcid":"0000-0001-7349-6455","position":13,"is_corresponding":false},{"id":300980,"name":"Laurent Gapin","orcid":"0000-0001-9730-5174","position":14,"is_corresponding":false},{"id":351178,"name":"Ross M. Kedl","orcid":"0000-0002-9065-7895","position":15,"is_corresponding":false},{"id":575818,"name":"Jared Klarquist","orcid":"0000-0002-4072-3962","position":16,"is_corresponding":false},{"id":993979,"name":"Cameron Manes","orcid":null,"position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:54:16.596730Z","pmid":"40244703","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}