{"doi":"10.1172/jci186231","title":"The arc of discovery, from the description of cystic fibrosis to effective treatments","abstract":"The story of investigation and discovery that led to effective treatments for cystic fibrosis (CF) might be considered a model for pursuing a genetic disease and developing successful therapies.It is apt to recount this story as we mark the 100th anniversary of the JCI because of the journal's tradition of describing the mechanistic bases of disease and an understanding of how they might be altered to impact human health.Let me begin by giving credit to the trainees, physicians, scientists, and caregivers around the world and in my own lab who propelled this journey.","journal":"Journal of Clinical Investigation","year":2024,"id":469343,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9484,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":401889,"name":"Michael J. Welsh","orcid":"0000-0002-1646-6206","position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:05:28.027781Z","pmid":"39352390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}