{"doi":"10.1172/jci172890","title":"Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics","abstract":"Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms. Aged male (23-32 months old) and female (27-28 months old) C57BL/6J mice were classified as non-, probable-, or sarcopenic based on assessments of grip strength, muscle mass, and treadmill running time, using 2 SDs below the mean of their young counterparts as cutoff points. A 9%-22% prevalence of sarcopenia was identified in 23-26 month-old male mice, with more severe age-related declines in muscle function than mass. Females aged 27-28 months showed fewer sarcopenic but more probable cases compared with the males. As sarcopenia progressed, a decrease in muscle contractility and a trend toward lower type IIB fiber size were observed in males. Mitochondrial biogenesis, oxidative capacity, and AMPK-autophagy signaling decreased as sarcopenia progressed in males, with pathways linked to mitochondrial metabolism positively correlated with muscle mass. No age- or sarcopenia-related changes were observed in mitochondrial biogenesis, OXPHOS complexes, AMPK signaling, mitophagy, or atrogenes in females. Our results highlight the different trajectories of age-related declines in muscle mass and function, providing insights into sex-dependent molecular changes associated with sarcopenia progression, which may inform the future development of novel therapeutic interventions.","journal":"Journal of Clinical Investigation","year":2024,"id":418899,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":732107,"name":"Kora Krumm","orcid":null,"position":1,"is_corresponding":false},{"id":365254,"name":"Bárbara Anderson","orcid":null,"position":2,"is_corresponding":false},{"id":685669,"name":"Anthony Christiani","orcid":null,"position":3,"is_corresponding":false},{"id":1076356,"name":"Lena Strait","orcid":null,"position":4,"is_corresponding":false},{"id":732108,"name":"Theresa Li","orcid":null,"position":5,"is_corresponding":false},{"id":732109,"name":"Brynn Irwin","orcid":null,"position":6,"is_corresponding":false},{"id":1075894,"name":"Siyi Jiang","orcid":"0000-0002-5481-2771","position":7,"is_corresponding":false},{"id":1076357,"name":"Artur Rybachok","orcid":null,"position":8,"is_corresponding":false},{"id":1075895,"name":"Amanda Chen","orcid":"0000-0001-9600-9357","position":9,"is_corresponding":false},{"id":1076358,"name":"Elizabeth Dacek","orcid":null,"position":10,"is_corresponding":false},{"id":1075896,"name":"Lucas Caeiro","orcid":"0000-0001-9633-3384","position":11,"is_corresponding":false},{"id":484474,"name":"Gennifer E. Merrihew","orcid":"0000-0003-4903-0318","position":12,"is_corresponding":false},{"id":419808,"name":"James W. MacDonald","orcid":"0000-0002-7328-7626","position":13,"is_corresponding":false},{"id":321863,"name":"Theo K. Bammler","orcid":null,"position":14,"is_corresponding":false},{"id":79569,"name":"Michael J. MacCoss","orcid":"0000-0003-1853-0256","position":15,"is_corresponding":false},{"id":363495,"name":"José M. Garcia","orcid":"0000-0002-4245-1753","position":16,"is_corresponding":false},{"id":1075893,"name":"Haiming L Kerr","orcid":"0000-0003-3142-3690","position":0,"is_corresponding":true}],"reference_count":95,"raw_metadata":null,"created_at":"2026-07-19T01:57:09.067930Z","pmid":"39145448","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}