{"doi":"10.1172/jci169112","title":"The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation","abstract":"One of the features of pathological cardiac hypertrophy is enhanced translation and protein synthesis. Translational inhibition has been shown to be an effective means of treating cardiac hypertrophy, although system-wide side effects are common. Regulators of translation, such as cardiac-specific long noncoding RNAs (lncRNAs), could provide new, more targeted therapeutic approaches to inhibit cardiac hypertrophy. Therefore, we generated mice lacking a previously identified lncRNA named CARDINAL to examine its cardiac function. We demonstrate that CARDINAL is a cardiac-specific, ribosome-associated lncRNA and show that its expression was induced in the heart upon pathological cardiac hypertrophy and that its deletion in mice exacerbated stress-induced cardiac hypertrophy and augmented protein translation. In contrast, overexpression of CARDINAL attenuated cardiac hypertrophy in vivo and in vitro and suppressed hypertrophy-induced protein translation. Mechanistically, CARDINAL interacted with developmentally regulated GTP-binding protein 1 (DRG1) and blocked its interaction with DRG family regulatory protein 1 (DFRP1); as a result, DRG1 was downregulated, thereby modulating the rate of protein translation in the heart in response to stress. This study provides evidence for the therapeutic potential of targeting cardiac-specific lncRNAs to suppress disease-induced translational changes and to treat cardiac hypertrophy and heart failure.","journal":"Journal of Clinical Investigation","year":2024,"id":434024,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":952754,"name":"Tiqun Yang","orcid":null,"position":1,"is_corresponding":false},{"id":506679,"name":"Yao Wei Lu","orcid":"0000-0001-6200-2974","position":2,"is_corresponding":false},{"id":861767,"name":"Gengze Wu","orcid":"0000-0002-1992-5308","position":3,"is_corresponding":false},{"id":1240187,"name":"Gang Dai","orcid":"0000-0001-8035-6143","position":4,"is_corresponding":false},{"id":506683,"name":"Qing Ma","orcid":"0000-0002-5625-1330","position":5,"is_corresponding":false},{"id":1065987,"name":"Mingming Zhang","orcid":"0000-0001-8480-0280","position":6,"is_corresponding":false},{"id":1240188,"name":"Huimin Zhou","orcid":"0000-0001-8297-2003","position":7,"is_corresponding":false},{"id":952753,"name":"Tianxin Long","orcid":null,"position":8,"is_corresponding":false},{"id":952752,"name":"Youchen Yan","orcid":null,"position":9,"is_corresponding":false},{"id":1236871,"name":"Zhuomin Liang","orcid":"0000-0001-6754-9346","position":10,"is_corresponding":false},{"id":530491,"name":"Chen Liu","orcid":"0000-0002-9818-0454","position":11,"is_corresponding":false},{"id":264279,"name":"William T. Pu","orcid":"0000-0002-4551-8079","position":12,"is_corresponding":false},{"id":775783,"name":"Yugang Dong","orcid":"0009-0001-0668-8788","position":13,"is_corresponding":false},{"id":1240189,"name":"Jing‐Song Ou","orcid":"0000-0001-5517-3142","position":14,"is_corresponding":false},{"id":1240190,"name":"Hong Chen","orcid":"0000-0002-2194-9042","position":15,"is_corresponding":false},{"id":966896,"name":"John D. Mably","orcid":"0000-0002-3626-9090","position":16,"is_corresponding":false},{"id":531167,"name":"Jiangui He","orcid":null,"position":17,"is_corresponding":false},{"id":1240732,"name":"Da-Zhi Wang","orcid":null,"position":18,"is_corresponding":false},{"id":357444,"name":"Zhan‐Peng Huang","orcid":null,"position":19,"is_corresponding":false},{"id":245655,"name":"Xin He","orcid":"0000-0002-2131-2092","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:59:53.957667Z","pmid":"38743498","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}