{"doi":"10.1172/jci158903","title":"Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells","abstract":null,"journal":"Journal of Clinical Investigation","year":2023,"id":641044,"datarank":0.6628260911694899,"base_score":4.418840607796598,"endowment":4.418840607796598,"self_citation_contribution":0.6628260911694899,"citation_network_contribution":0.0,"self_endowment_contribution":0.6628260911694899,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":82,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1031000,"name":"Deeqa Mahamed","orcid":"0000-0002-0382-844X","position":1,"is_corresponding":false},{"id":1666413,"name":"Adrian Kuipery","orcid":"0000-0002-4790-2234","position":2,"is_corresponding":false},{"id":1666414,"name":"Juan D. Sanchez Vasquez","orcid":null,"position":3,"is_corresponding":false},{"id":266701,"name":"Samuel Kim","orcid":"0000-0001-5237-6358","position":4,"is_corresponding":false},{"id":1031560,"name":"Aman Mehrotra","orcid":null,"position":5,"is_corresponding":false},{"id":1661568,"name":"Anjali Patel","orcid":null,"position":6,"is_corresponding":false},{"id":757751,"name":"Christine Hu","orcid":null,"position":7,"is_corresponding":false},{"id":1666415,"name":"Ian McGilvray","orcid":null,"position":8,"is_corresponding":false},{"id":28335,"name":"Jordan J. Feld","orcid":"0000-0003-2640-2211","position":9,"is_corresponding":false},{"id":1539155,"name":"Scott Fung","orcid":null,"position":10,"is_corresponding":false},{"id":1666416,"name":"Diana Chen","orcid":null,"position":11,"is_corresponding":false},{"id":646084,"name":"Jeffrey J. Wallin","orcid":"0000-0002-5952-3813","position":12,"is_corresponding":false},{"id":356371,"name":"Anuj Gaggar","orcid":"0000-0001-7865-001X","position":13,"is_corresponding":false},{"id":270563,"name":"Harry L.A. Janssen","orcid":"0000-0003-2398-8392","position":14,"is_corresponding":false},{"id":806779,"name":"Adam J. Gehring","orcid":"0000-0003-1150-5840","position":15,"is_corresponding":false},{"id":1031005,"name":"Shirin Nkongolo","orcid":"0000-0002-0197-083X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Longitudinal liver sampling in patients with chronic hepatitis B starting antiviral therapy reveals hepatotoxic CD8+ T cells","abstract":"Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the underlying mechanisms in humans and to define whether these are driven by widespread activation or a subpopulation of immune cells. We enrolled CHB patients with active liver damage to receive antiviral therapy and performed longitudinal liver sampling using fine-needle aspiration to investigate mechanisms of CHB pathogenesis in the human liver. Single-cell sequencing of total liver cells revealed a distinct liver-resident, polyclonal CD8+ T cell population that was enriched at baseline and displayed a highly activated immune signature during liver damage. Cytokine combinations, identified by in silico prediction of ligand-receptor interaction, induced the activated phenotype in healthy liver CD8+ T cells, resulting in nonspecific Fas ligand-mediated killing of target cells. These results define a CD8+ T cell population in the human liver that can drive pathogenesis and a key pathway involved in their function in CHB patients.","is_dataset_classified":null,"base_score":4.418840607796598,"endowment":4.418840607796598,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36594467","pmcid":"PMC9797343","openalex_id":"https://openalex.org/W4313427367","authors":[],"funders":[{"funder_name":"Gilead Sciences","grant_id":"NCT04070079","title":null},{"funder_name":"German Research Foundation","grant_id":"442362849","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":13.8342,"citation_percentile":0.99413998,"influential_citations":0,"citation_trend":[{"year":2023,"count":23},{"year":2024,"count":27},{"year":2025,"count":22},{"year":2026,"count":10}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.jci.org/articles/view/158903/files/pdf","host_type":"journal"},{"url":"http://www.jci.org/articles/view/158903/files/pdf","host_type":"publisher"},{"url":"https://www.jci.org/articles/view/158903/files/pdf","host_type":"publisher"},{"url":"https://doi.org/10.1172/jci158903","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36594467","host_type":"repository"},{"url":"https://pure.eur.nl/en/publications/e0d920e7-882b-4ee5-b0b0-a5a49bd1b6bd","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9797343","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9797343/pdf/jci-133-158903.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9797343","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9797343?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1172/JCI158903","host_type":""},{"url":"https://doaj.org/article/3de81f98e7904dffa98ecc61f04fe620","host_type":""},{"url":"https://doi.org/10.1172/JCI158903","host_type":""}],"fields_of_study":["SARS-CoV-2 and COVID-19 Research","Hepatitis B Virus Studies","T-cell and B-cell Immunology","0301 basic medicine","03 medical and health sciences","Humans","Hepatitis B, Chronic","CD8-Positive T-Lymphocytes","Liver Cirrhosis","Antiviral Agents","Hepatitis B virus"],"mesh_terms":["Antiviral Agents","Hepatitis B virus","Humans","Liver Cirrhosis","CD8-Positive T-Lymphocytes","Hepatitis B, Chronic"],"keywords":["CD8","Immunology","Immune system","Cytotoxic T cell","Pathogenesis","T cell","Population","Cirrhosis","Hepatocyte","Biology","Hepatitis","Medicine","Internal medicine","In vitro","T cells","Infectious disease","cellular immune response","Liver Cirrhosis","Hepatitis B virus","R","CD8-Positive T-Lymphocytes","Antiviral Agents","Hepatitis B, Chronic","SDG 3 - Good Health and Well-being","Humans","Research Article"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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