{"doi":"10.1172/jci154515","title":"β-Catenin signaling in hepatocellular carcinoma","abstract":"Deregulated Wnt/β-catenin signaling is one of the main genetic alterations in human hepatocellular carcinoma (HCC). Comprehensive genomic analyses have revealed that gain-of-function mutation of CTNNB1, which encodes β-catenin, and loss-of-function mutation of AXIN1 occur in approximately 35% of human HCC samples. Human HCCs with activation of the Wnt/β-catenin pathway demonstrate unique gene expression patterns and pathological features. Activated Wnt/β-catenin synergizes with multiple signaling cascades to drive HCC formation, and it functions through its downstream effectors. Therefore, strategies targeting Wnt/β-catenin have been pursued as possible therapeutics against HCC. Here, we review the genetic alterations and oncogenic roles of aberrant Wnt/β-catenin signaling during hepatocarcinogenesis. In addition, we discuss the implication of this pathway in HCC diagnosis, classification, and personalized treatment.","journal":"Journal of Clinical Investigation","year":2022,"id":232024,"datarank":0.8515130703402424,"base_score":5.676753802268282,"endowment":5.676753802268282,"self_citation_contribution":0.8515130703402424,"citation_network_contribution":0.0,"self_endowment_contribution":0.8515130703402424,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":291,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1342,"name":"Zhong Xu","orcid":"0000-0001-7565-6053","position":1,"is_corresponding":false},{"id":105589,"name":"Yi Zhang","orcid":"0000-0002-8228-2560","position":2,"is_corresponding":false},{"id":278057,"name":"Matthias Evert","orcid":"0009-0001-8412-9682","position":3,"is_corresponding":false},{"id":270014,"name":"Diego F. Calvisi","orcid":"0000-0002-6038-8567","position":4,"is_corresponding":false},{"id":1360,"name":"Xin Chen","orcid":"0000-0002-9588-0164","position":5,"is_corresponding":false},{"id":255513,"name":"Chuanrui Xu","orcid":"0000-0003-3225-4083","position":0,"is_corresponding":true}],"reference_count":155,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:20:51.245255Z","pmid":"35166233","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}