{"doi":"10.1172/jci153563","title":"A nerve injury–specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression","abstract":"Maladaptive changes of nerve injury-associated genes in dorsal root ganglia (DRGs) are critical for neuropathic pain genesis. Emerging evidence supports the role of long noncoding RNAs (lncRNAs) in regulating gene transcription. Here we identified a conserved lncRNA, named nerve injury-specific lncRNA (NIS-lncRNA) for its upregulation in injured DRGs exclusively in response to nerve injury. This upregulation was triggered by nerve injury-induced increase in DRG ELF1, a transcription factor that bound to the NIS-lncRNA promoter. Blocking this upregulation attenuated nerve injury-induced CCL2 increase in injured DRGs and nociceptive hypersensitivity during the development and maintenance periods of neuropathic pain. Mimicking NIS-lncRNA upregulation elevated CCL2 expression, increased CCL2-mediated excitability in DRG neurons, and produced neuropathic pain symptoms. Mechanistically, NIS-lncRNA recruited more binding of the RNA-interacting protein FUS to the Ccl2 promoter and augmented Ccl2 transcription in injured DRGs. Thus, NIS-lncRNA participates in neuropathic pain likely by promoting FUS-triggered DRG Ccl2 expression and may be a potential target in neuropathic pain management.","journal":"Journal of Clinical Investigation","year":2022,"id":234124,"datarank":0.7023196840686331,"base_score":4.68213122712422,"endowment":4.68213122712422,"self_citation_contribution":0.7023196840686331,"citation_network_contribution":0.0,"self_endowment_contribution":0.7023196840686331,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":107,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9503,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":289055,"name":"Shaogen Wu","orcid":"0000-0001-5653-3357","position":1,"is_corresponding":false},{"id":650000,"name":"Xiaozhou Feng","orcid":"0000-0002-2963-0546","position":2,"is_corresponding":false},{"id":337341,"name":"Bing Wang","orcid":"0000-0002-2918-8583","position":3,"is_corresponding":false},{"id":289058,"name":"Shangzhou Xia","orcid":"0000-0001-9871-739X","position":4,"is_corresponding":false},{"id":361156,"name":"Lingli Liang","orcid":"0000-0001-7594-387X","position":5,"is_corresponding":false},{"id":291057,"name":"Li Zhang","orcid":"0000-0002-9386-8938","position":6,"is_corresponding":false},{"id":850184,"name":"Gokulapriya Govindarajalu","orcid":null,"position":7,"is_corresponding":false},{"id":497607,"name":"Alexander T. Bunk","orcid":"0000-0002-3779-759X","position":8,"is_corresponding":false},{"id":730266,"name":"Feni Kadakia","orcid":"0000-0002-0894-7309","position":9,"is_corresponding":false},{"id":457004,"name":"Qingxiang Mao","orcid":"0000-0002-9268-4846","position":10,"is_corresponding":false},{"id":289054,"name":"Xinying Guo","orcid":"0000-0002-8428-5036","position":11,"is_corresponding":false},{"id":477254,"name":"Hui Zhao","orcid":"0000-0001-7747-2100","position":12,"is_corresponding":false},{"id":241407,"name":"Tolga Berkman","orcid":"0000-0002-3124-1371","position":13,"is_corresponding":false},{"id":495455,"name":"Tong Liu","orcid":"0000-0001-9152-5264","position":14,"is_corresponding":false},{"id":298613,"name":"Hong Li","orcid":"0000-0001-5731-5335","position":15,"is_corresponding":false},{"id":850185,"name":"Jordan Stillman","orcid":null,"position":16,"is_corresponding":false},{"id":414501,"name":"Alex Bekker","orcid":"0000-0002-6785-6714","position":17,"is_corresponding":false},{"id":399830,"name":"Steve Davidson","orcid":"0000-0003-2944-1144","position":18,"is_corresponding":false},{"id":289060,"name":"Yuan‐Xiang Tao","orcid":"0000-0003-1777-3272","position":19,"is_corresponding":false},{"id":290418,"name":"Shibin Du","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:21:36.529874Z","pmid":"35775484","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}