{"doi":"10.1172/jci151975","title":"Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation","abstract":"Little is known about how cells regulate and integrate distinct biosynthetic pathways governing differentiation and cell division. For B lineage cells it is widely accepted that activated cells must complete several rounds of mitosis before yielding antibody-secreting plasma cells. However, we report that marginal zone (MZ) B cells, innate-like naive B cells known to generate plasma cells rapidly in response to blood-borne bacteria, generate functional plasma cells despite cell-cycle arrest. Further, short-term Notch2 blockade in vivo reversed division-independent differentiation potential and decreased transcript abundance for numerous mTORC1- and Myc-regulated genes. Myc loss compromised plasma cell differentiation for MZ B cells, and reciprocally induced ectopic mTORC1 signaling in follicular B cells enabled division-independent differentiation and plasma cell-affiliated gene expression. We conclude that ongoing in situ Notch2/mTORC1 signaling in MZ B cells establishes a unique cellular state that enables rapid division-independent plasma cell differentiation.","journal":"Journal of Clinical Investigation","year":2021,"id":158640,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":667967,"name":"Carly Roman","orcid":"0000-0002-9431-7548","position":1,"is_corresponding":false},{"id":667968,"name":"Trini A. Ochoa","orcid":"0000-0002-1145-7669","position":2,"is_corresponding":false},{"id":233973,"name":"Daniela Gómez Atria","orcid":null,"position":3,"is_corresponding":false},{"id":271756,"name":"Derek D. Jones","orcid":"0000-0001-9982-0065","position":4,"is_corresponding":false},{"id":226257,"name":"Christian W. Siebel","orcid":"0000-0003-4333-3756","position":5,"is_corresponding":false},{"id":227869,"name":"Ivan Maillard","orcid":"0000-0003-1312-6748","position":6,"is_corresponding":false},{"id":230388,"name":"David Allman","orcid":"0000-0001-9345-1502","position":7,"is_corresponding":false},{"id":230381,"name":"Brian T. Gaudette","orcid":"0000-0001-6627-3085","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-18T23:44:30.791367Z","pmid":"34473651","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}