{"doi":"10.1172/jci146686","title":"Natural killer cell immunosuppressive function requires CXCR3-dependent redistribution within lymphoid tissues","abstract":"NK cell suppression of T cells is a key determinant of viral pathogenesis and vaccine efficacy. This process involves perforin-dependent elimination of activated CD4+ T cells during the first 3 days of infection. Although this mechanism requires cell-cell contact, NK cells and T cells typically reside in different compartments of lymphoid tissues at steady state. Here, we showed that NK cell suppression of T cells is associated with transient accumulation of NK cells within T cell-rich sites of the spleen during lymphocytic choriomeningitis virus infection. The chemokine receptor CXCR3 was required for this relocation and suppression of antiviral T cells. Accordingly, NK cell migration was mediated by type I IFN-dependent promotion of CXCR3 ligand expression. In contrast, adenoviral vectors that weakly induced type I IFN and did not stimulate NK cell inhibition of T cells also did not promote measurable redistribution of NK cells to T cell zones. Exogenous IFN rescued NK cell migration during adenoviral vector immunization. Thus, type I IFN and CXCR3 were critical for properly positioning NK cells to constrain antiviral T cell responses. Development of strategies to curtail migration of NK cells between lymphoid compartments may enhance vaccine-elicited immune responses.","journal":"Journal of Clinical Investigation","year":2021,"id":158404,"datarank":1.4200815290739122,"base_score":3.8712010109078907,"endowment":3.8712010109078907,"self_citation_contribution":0.5806801516361837,"citation_network_contribution":0.8394013774377285,"self_endowment_contribution":0.5806801516361837,"citer_contribution":0.8394013774377285,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":41,"citers_with_citation_signal":33,"citers_with_endowment":33,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.955,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":655336,"name":"Laura M. Canaday","orcid":"0000-0002-8053-2431","position":1,"is_corresponding":false},{"id":655335,"name":"H. Alex Feldman","orcid":"0000-0002-3281-2535","position":2,"is_corresponding":false},{"id":521336,"name":"Hilal Cevik","orcid":null,"position":3,"is_corresponding":false},{"id":668464,"name":"Michael T. Moran","orcid":null,"position":4,"is_corresponding":false},{"id":667507,"name":"Sanjeeth Rajaram","orcid":"0000-0002-9336-422X","position":5,"is_corresponding":false},{"id":655337,"name":"Nora Lakes","orcid":"0000-0002-8398-9680","position":6,"is_corresponding":false},{"id":353795,"name":"Jasmine A. Tuazon","orcid":"0000-0001-9896-9714","position":7,"is_corresponding":false},{"id":521338,"name":"Harsha Seelamneni","orcid":null,"position":8,"is_corresponding":false},{"id":521335,"name":"Durga Krishnamurthy","orcid":null,"position":9,"is_corresponding":false},{"id":364418,"name":"Eryn Blass","orcid":"0000-0003-0519-5022","position":10,"is_corresponding":false},{"id":106527,"name":"Dan H. Barouch","orcid":"0000-0001-5127-4659","position":11,"is_corresponding":false},{"id":274431,"name":"Stephen N. Waggoner","orcid":"0000-0001-9658-2874","position":12,"is_corresponding":false},{"id":353794,"name":"Ayad Ali","orcid":"0000-0002-0213-9511","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:44:30.791367Z","pmid":"34314390","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}