{"doi":"10.1172/jci141777","title":"Favorable outcomes of COVID-19 in recipients of hematopoietic cell transplantation","abstract":"BACKGROUNDUnderstanding outcomes and immunologic characteristics of cellular therapy recipients with SARS-CoV-2 is critical to performing these potentially life-saving therapies in the COVID-19 era. In this study of recipients of allogeneic (Allo) and autologous (Auto) hematopoietic cell transplant and CD19-directed chimeric antigen receptor T cell (CAR T) therapy at Memorial Sloan Kettering Cancer Center, we aimed to identify clinical variables associated with COVID-19 severity and assess lymphocyte populations.METHODSWe retrospectively investigated patients diagnosed between March 15, 2020, and May 7, 2020. In a subset of patients, lymphocyte immunophenotyping, quantitative real-time PCR from nasopharyngeal swabs, and SARS-CoV-2 antibody status were available.RESULTSWe identified 77 patients with SARS-CoV-2 who were recipients of cellular therapy (Allo, 35; Auto, 37; CAR T, 5; median time from cellular therapy, 782 days; IQR, 354-1611 days). Overall survival at 30 days was 78%. Clinical variables significantly associated with the composite endpoint of nonrebreather or higher oxygen requirement and death (n events = 25 of 77) included number of comorbidities (HR 5.41, P = 0.004), infiltrates (HR 3.08, P = 0.032), and neutropenia (HR 1.15, P = 0.04). Worsening graft-versus-host disease was not identified among Allo recipients. Immune profiling revealed reductions and rapid recovery in lymphocyte populations across lymphocyte subsets. Antibody responses were seen in a subset of patients.CONCLUSIONIn this series of Allo, Auto, and CAR T recipients, we report overall favorable clinical outcomes for patients with COVID-19 without active malignancy and provide preliminary insights into the lymphocyte populations that are key for the antiviral response and immune reconstitution.FUNDINGNIH grant P01 CA23766 and NIH/National Cancer Institute grant P30 CA008748.","journal":"Journal of Clinical Investigation","year":2020,"id":52928,"datarank":0.7254422860427218,"base_score":4.836281906951478,"endowment":4.836281906951478,"self_citation_contribution":0.7254422860427218,"citation_network_contribution":0.0,"self_endowment_contribution":0.7254422860427218,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":125,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":268582,"name":"Susan DeWolf","orcid":"0000-0002-2754-3537","position":1,"is_corresponding":false},{"id":268583,"name":"Yeon Joo Lee","orcid":"0000-0002-2997-0217","position":2,"is_corresponding":false},{"id":268584,"name":"Roni Tamari","orcid":"0000-0002-2386-0850","position":3,"is_corresponding":false},{"id":237600,"name":"Parastoo B. Dahi","orcid":"0000-0002-0794-3226","position":4,"is_corresponding":false},{"id":268585,"name":"Jessica A. Lavery","orcid":"0000-0002-2746-5647","position":5,"is_corresponding":false},{"id":269611,"name":"Josel D. Ruiz","orcid":null,"position":6,"is_corresponding":false},{"id":90690,"name":"Sean M. Devlin","orcid":"0000-0002-6801-720X","position":7,"is_corresponding":false},{"id":108866,"name":"Christina Cho","orcid":"0000-0002-7964-3011","position":8,"is_corresponding":false},{"id":108832,"name":"Jonathan U. Peled","orcid":null,"position":9,"is_corresponding":false},{"id":108868,"name":"Ioannis Politikos","orcid":"0000-0002-2854-8751","position":10,"is_corresponding":false},{"id":108867,"name":"Michael Scordo","orcid":"0000-0002-9484-0240","position":11,"is_corresponding":false},{"id":228382,"name":"N. Esther Babady","orcid":"0000-0003-4399-1249","position":12,"is_corresponding":false},{"id":268586,"name":"Tania Jain","orcid":"0000-0001-6854-773X","position":13,"is_corresponding":false},{"id":78951,"name":"Santosha A. Vardhana","orcid":"0000-0002-3100-1298","position":14,"is_corresponding":false},{"id":268587,"name":"Anthony F. Daniyan","orcid":"0009-0002-2742-2281","position":15,"is_corresponding":false},{"id":237601,"name":"Craig S. Sauter","orcid":"0000-0002-5316-8785","position":16,"is_corresponding":false},{"id":268588,"name":"Juliet N. Barker","orcid":"0000-0001-6693-0911","position":17,"is_corresponding":false},{"id":108874,"name":"Sergio Giralt","orcid":"0000-0003-1944-5053","position":18,"is_corresponding":false},{"id":268589,"name":"Cheryl Goss","orcid":"0000-0003-3435-175X","position":19,"is_corresponding":false},{"id":268590,"name":"P. Maslak","orcid":"0000-0003-1949-5819","position":20,"is_corresponding":false},{"id":228380,"name":"Tobias M. Hohl","orcid":"0000-0002-9097-5412","position":21,"is_corresponding":false},{"id":228383,"name":"Mini Kamboj","orcid":"0000-0002-3122-6374","position":22,"is_corresponding":false},{"id":268591,"name":"Lakshmi V. Ramanathan","orcid":"0000-0002-5440-5359","position":23,"is_corresponding":false},{"id":108880,"name":"Marcel R.M. van den Brink","orcid":"0000-0003-0696-4401","position":24,"is_corresponding":false},{"id":268592,"name":"Esperanza B. Papadopoulos","orcid":"0000-0001-6066-1861","position":25,"is_corresponding":false},{"id":228381,"name":"Genovefa A. Papanicolaou","orcid":"0000-0002-2891-079X","position":26,"is_corresponding":false},{"id":108873,"name":"Miguel‐Angel Perales","orcid":"0000-0002-5910-4571","position":27,"is_corresponding":false},{"id":108865,"name":"Gunjan L. Shah","orcid":"0000-0002-9977-0456","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T20:43:25.742124Z","pmid":"32897885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}