{"doi":"10.1172/jci141008","title":"IL-1β–driven osteoclastogenic Tregs accelerate bone erosion in arthritis","abstract":"IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in Tregs. Using mice with joint inflammation arising through deficiency of the IL-1 receptor antagonist (Il1rn-/-), we observed that IL-1β blockade attenuated disease more effectively in early arthritis than in established arthritis, especially with respect to bone erosion. Protection was accompanied by a reduction in synovial CD4+Foxp3+ Tregs that displayed preserved suppressive capacity and aerobic metabolism but aberrant expression of RANKL and a striking capacity to drive RANKL-dependent osteoclast differentiation. Both Il1rn-/- Tregs and wild-type Tregs differentiated with IL-1β accelerated bone erosion upon adoptive transfer. Human Tregs exhibited analogous differentiation, and corresponding RANKLhiFoxp3+ T cells could be identified in rheumatoid arthritis synovial tissue. Together, these findings identify IL-1β-induced osteoclastogenic Tregs as a contributor to bone erosion in arthritis.","journal":"Journal of Clinical Investigation","year":2021,"id":150453,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9448,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":230136,"name":"Margaret H. Chang","orcid":"0000-0002-3545-8957","position":1,"is_corresponding":false},{"id":641201,"name":"Julia T. Schnell","orcid":null,"position":2,"is_corresponding":false},{"id":618273,"name":"Nathan Nelson-Maney","orcid":"0000-0002-9388-2801","position":3,"is_corresponding":false},{"id":640041,"name":"Jing Yan","orcid":"0000-0001-6245-7434","position":4,"is_corresponding":false},{"id":640042,"name":"Marta Martínez‐Bonet","orcid":"0000-0003-0715-403X","position":5,"is_corresponding":false},{"id":297351,"name":"Ricardo Grieshaber‐Bouyer","orcid":"0000-0002-2873-5135","position":6,"is_corresponding":false},{"id":230129,"name":"Pui Y. Lee","orcid":"0000-0002-5779-4193","position":7,"is_corresponding":false},{"id":76150,"name":"Kevin Wei","orcid":"0000-0002-1821-167X","position":8,"is_corresponding":false},{"id":619601,"name":"Rachel B. Blaustein","orcid":null,"position":9,"is_corresponding":false},{"id":634492,"name":"Allyn Morris","orcid":"0000-0002-1932-6444","position":10,"is_corresponding":false},{"id":634493,"name":"Alexandra Wactor","orcid":"0000-0002-8735-7007","position":11,"is_corresponding":false},{"id":608927,"name":"Yoichiro Iwakura","orcid":"0000-0002-9934-5775","position":12,"is_corresponding":false},{"id":245205,"name":"James A. Lederer","orcid":"0000-0002-6445-252X","position":13,"is_corresponding":false},{"id":226249,"name":"Deepak A. Rao","orcid":"0000-0001-9672-7746","position":14,"is_corresponding":false},{"id":282931,"name":"Julia F. Charles","orcid":"0000-0002-5875-314X","position":15,"is_corresponding":false},{"id":257820,"name":"Peter A. Nigrović","orcid":"0000-0002-2126-3702","position":16,"is_corresponding":false},{"id":266338,"name":"Anaïs Levescot","orcid":"0000-0002-3892-9347","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-18T23:43:06.501849Z","pmid":"34343136","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}