{"doi":"10.1172/jci135468","title":"Tissue-resident PSGL1loCD4+ T cells promote B cell differentiation and chronic graft-versus-host disease–associated autoimmunity","abstract":"CD4+ T cell interactions with B cells play a critical role in the pathogenesis of systemic autoimmune diseases such as systemic lupus and chronic graft-versus-host disease (cGVHD). Extrafollicular CD44hiCD62LloPSGL1loCD4+ T cells (PSGL1loCD4+ T cells) are associated with the pathogenesis of lupus and cGVHD, but their causal role has not been established. With murine and humanized MHC-/-HLA-A2+DR4+ murine models of cGVHD, we showed that murine and human PSGL1loCD4+ T cells from GVHD target tissues have features of B cell helpers with upregulated expression of programmed cell death protein 1 (PD1) and inducible T cell costimulator (ICOS) and production of IL-21. They reside in nonlymphoid tissues without circulating in the blood and have features of tissue-resident memory T cells with upregulated expression of CD69. Murine PSGL1loCD4+ T cells from GVHD target tissues augmented B cell differentiation into plasma cells and production of autoantibodies via their PD1 interaction with PD-L2 on B cells. Human PSGL1loCD4+ T cells were apposed with memory B cells in the liver tissues of humanized mice and cGVHD patients. Human PSGL1loCD4+ T cells from humanized GVHD target tissues also augmented autologous memory B cell differentiation into plasma cells and antibody production in a PD1/PD-L2-dependent manner. Further preclinical studies targeting tissue-resident T cells to treat antibody-mediated features of autoimmune diseases are warranted.","journal":"Journal of Clinical Investigation","year":2020,"id":95517,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9481,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":475916,"name":"Deye Zeng","orcid":null,"position":1,"is_corresponding":false},{"id":108571,"name":"Xiwei Wu","orcid":"0000-0002-7071-1671","position":2,"is_corresponding":false},{"id":474657,"name":"Bixin Wang","orcid":"0009-0000-9613-2734","position":3,"is_corresponding":false},{"id":474658,"name":"Shijie Yang","orcid":"0000-0003-3452-3638","position":4,"is_corresponding":false},{"id":474659,"name":"Qingxiao Song","orcid":"0000-0001-9243-5666","position":5,"is_corresponding":false},{"id":475917,"name":"Yongping Zhu","orcid":null,"position":6,"is_corresponding":false},{"id":322440,"name":"Martha Salas","orcid":"0009-0006-0159-5896","position":7,"is_corresponding":false},{"id":108565,"name":"Hanjun Qin","orcid":"0000-0002-0370-0913","position":8,"is_corresponding":false},{"id":475918,"name":"Ubaydah Nasri","orcid":null,"position":9,"is_corresponding":false},{"id":474660,"name":"Karen M. Haas","orcid":"0000-0002-9951-1964","position":10,"is_corresponding":false},{"id":283022,"name":"Arthur D. Riggs","orcid":"0000-0002-8184-5288","position":11,"is_corresponding":false},{"id":284156,"name":"Ryotaro Nakamura","orcid":"0000-0002-9082-0680","position":12,"is_corresponding":false},{"id":236735,"name":"Paul J. Martin","orcid":"0000-0001-9051-1215","position":13,"is_corresponding":false},{"id":474661,"name":"Aimin Huang","orcid":"0000-0002-3141-0315","position":14,"is_corresponding":false},{"id":474662,"name":"Defu Zeng","orcid":"0000-0001-9585-1411","position":15,"is_corresponding":false},{"id":474656,"name":"Xiaohui Kong","orcid":"0000-0002-8353-3288","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T22:33:57.534608Z","pmid":"32931481","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}