{"doi":"10.1172/jci134778","title":"β-Glucan–induced reprogramming of human macrophages inhibits NLRP3 inflammasome activation in cryopyrinopathies","abstract":"Exposure of mononuclear phagocytes to β-glucan, a naturally occurring polysaccharide, contributes to the induction of innate immune memory, which is associated with long-term epigenetic, metabolic, and functional reprogramming. Although previous studies have shown that innate immune memory induced by β-glucan confers protection against secondary infections, its impact on autoinflammatory diseases, associated with inflammasome activation and IL-1β secretion, remains poorly understood. In particular, whether β-glucan-induced long-term reprogramming affects inflammasome activation in human macrophages in the context of these diseases has not been explored. We found that NLRP3 inflammasome-mediated caspase-1 activation and subsequent IL-1β production were reduced in β-glucan-reprogrammed macrophages. β-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation. Importantly, β-glucan-induced memory in macrophages resulted in a remarkable attenuation of IL-1β secretion and caspase-1 activation in patients with an NLRP3-associated autoinflammatory disease, cryopyrin-associated periodic syndromes (CAPS). Our findings demonstrate that β-glucan-induced innate immune memory represses IL-1β-mediated inflammation and support its potential clinical use in NLRP3-driven diseases.","journal":"Journal of Clinical Investigation","year":2020,"id":57807,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":76,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9389,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":302227,"name":"Mathieu Bohm","orcid":"0000-0001-5090-1569","position":1,"is_corresponding":false},{"id":302228,"name":"Alícia Corbellini Piffer","orcid":"0000-0001-9324-9806","position":2,"is_corresponding":false},{"id":303447,"name":"Rachel Lavenir","orcid":null,"position":3,"is_corresponding":false},{"id":225206,"name":"David L. Williams","orcid":"0000-0002-4586-9290","position":4,"is_corresponding":false},{"id":281907,"name":"Bénédicte Neven","orcid":"0000-0001-8941-0935","position":5,"is_corresponding":false},{"id":302229,"name":"Gilles Grateau","orcid":"0000-0002-8767-7385","position":6,"is_corresponding":false},{"id":302230,"name":"Sophie Georgin‐Lavialle","orcid":"0000-0001-6668-8854","position":7,"is_corresponding":false},{"id":302231,"name":"Jessica Quintin","orcid":"0000-0002-1589-9034","position":8,"is_corresponding":false},{"id":302226,"name":"Giorgio Camilli","orcid":"0000-0002-6662-0072","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-18T21:06:48.611399Z","pmid":"32716363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}